TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.1.4.8
Inward rectifying Shaker K+ channel SPIK (AKT6) (expressed in pollen, and involved in pollen tube development) (Mouline et al., 2002).

Accession Number:Q8GXE6
Protein Name:SPIK aka AKT6
Length:888
Molecular Weight:99215.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

Genevestigator: Q8GXE6
eggNOG: KOG0498
HEGENOM: HBG318539
Pfam: PF00023    PF00027    PF11834    PF00520   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005249 F:voltage-gated potassium channel activity
GO:0006813 P:potassium ion transport
GO:0055085 P:transmembrane transport

References (5)

[1] “Pollen tube development and competitive ability are impaired by disruption of a Shaker K(+) channel in Arabidopsis.”  Mouline K.et.al.   11825875
[2] “Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.”  Lin X.et.al.   10617197
[3] “Functional annotation of a full-length Arabidopsis cDNA collection.”  Seki M.et.al.   11910074
[4] “A shaker-like K(+) channel with weak rectification is expressed in both source and sink phloem tissues of Arabidopsis.”  Lacombe B.et.al.   10852932
[5] “Phylogenetic relationships within cation transporter families of Arabidopsis.”  Maeser P.et.al.   11500563

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MEKKKVWFWG VKDDGEGGGG RGGGRTKDAE DDVADHLSRD GTMSQYSLSK GLLPSLGANN 
61:	RSSRDVILPR FIVSPFDPRY RAWETFLVFL VLYTAWASPF EFGFLQKPRP PLSILDNIVN 
121:	GFFAVDIVLT FFVAFLDKVT YLLVDDPKRI AWRYASTWLI FDVVSTFPYE IFGSLLHESI 
181:	QGYGIFSMLR LWRLRRVSNC FARLEKDRKY SYFWVRCSKL LLVTLFVIHC GACFLYSIAA 
241:	HYPDPSKTFM ALTDENWKES PIAVRYNTAM YWSITTFSTT GYGDIHGVNS REMTFILFYM 
301:	VFNLGLSAYI IGNMTNLVVH VTGRTRKFRD TIQAASGFGQ RNNLPVRLQD QMVAHLCLRY 
361:	RTDSEGLQQQ EIIDSLPKAI RSSISHYLFY EVVDKIYLFH GISNDLLFQL VTEMKAEYFP 
421:	PKEDVILQNE APTDFYILVT GAVDIIARVN GVEQVVSEAQ RGHVFGEVGV LCYRPQLFTV 
481:	RTKRLSQLLR LNRTVLLNLV QANVGDGAII MNNLLQHLKD SEDPVMKGVL ADTEHMLAQG 
541:	KMDLPLSLCF AAARGDDLLL HQLLRRGSSP NEMDKDGRTA LHIAASKGSH YCVVLLLEHG 
601:	ADPNIRDSEG NVPLWEAIIG RHREIAKLLA ENGAKLSLDS VSYFSGLAVE KNCLDALKDI 
661:	IKYGGDVTLP DGNGTTALHR AVSEGHLEIV KFLLDQGADL DWPDSYGWTP RGLADHQGNE 
721:	EIKTLFHNHR PVEKKPKPIP GIPQSPVTGK PLMKYSSEPT MHSGELVLDG GQVVVSQKRK 
781:	LNNFRNSLFG IISAANSADD GGEVPRSPAV PGGGGSMIYP ERVTISSPEN GETGGKVVLL 
841:	PNSMEELLKI GENKMGFVPT KVLTREGAEI DDITLIRDGD FLLLSRDP