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1.A.1.4.9
The KC1 (KAT3) potassium channel-like subunit; regulates other channels such as AKT1 (1.A.1.4.1) and KAT1 (1.A.1.4.7) (Duby et al., 2008); may form heteromeric channels with AKT1 (Geiger et al., 2009). It forms a tripartite SNARE-K+ channel complex which regulates KAT3 channel opening (Honsbein et al., 2009).  Tripartite interactions with SNARE (SYP121; SYR1; PEN1) and AKT1 control gating (Grefen et al. 2010).  ZKC1 also forms homoleric channels in the endoplasmic reticulum (Nieves-Cordones et al. 2014).

Accession Number:P92960
Protein Name:KC1 or KAT3
Length:662
Molecular Weight:75598.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

Genevestigator: P92960
eggNOG: KOG0498
HEGENOM: HBG318539
RefSeq: NP_194991.1   
Entrez Gene ID: 829400   
Pfam: PF00027    PF11834    PF00520   

Gene Ontology

GO:0005783 C:endoplasmic reticulum
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005249 F:voltage-gated potassium channel activity
GO:0006813 P:potassium ion transport
GO:0009624 P:response to nematode
GO:0055085 P:transmembrane transport

References (5)

[1] “Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.”  Mayer K.F.X.et.al.   10617198
[2] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[3] “Phylogenetic relationships within cation transporter families of Arabidopsis.”  Maeser P.et.al.   11500563
[4] “AtKC1, a silent Arabidopsis potassium channel alpha-subunit modulates root hair K+ influx.”  Reintanz B.et.al.   11904452
[5] “Regulated expression of Arabidopsis shaker K(+) channel genes involved in K(+) uptake and distribution in the plant.”  Pilot G.et.al.   12678562

External Searches:

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  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSTTTTEARS PLPLLLRRGR SSTALSASTA EARSPLSILQ FRRRSSKDVR NITSVSSSLL 
61:	PAFGTFIEDD NPSSKPFIVL HFDRRYRLWE LFLVILVGYS AWASLFELAF EKAAEGALLT 
121:	IDLVVDFFFA VDIILTFFVS YLDNTTYLNV TDHKLIAKRY LKSVAFVMDV ASTLPIQFIY 
181:	KTITGDVGRG QAFGFLNLLR LWRLRRVAEL FKRLEKDAHF NYFVIRVIKL LCVTIFWIHL 
241:	AGCILYWIAY HYPRPTDTWI GSQVEDFKER SVWLGYTYSM YWSIVTLTTV GYGDLHAVNS 
301:	REKTFNMFYM LFNIGLTSYI IGIMTNLVVH GALRTFAMRS AINDILRYTS KNRLPDTMRE 
361:	QMLAHMQLKF KTAELRQEEV LQDLPKAIRS SINQHLFRSI IEEAYLFKGF PEGLLVQLVS 
421:	QIQAEYFPPK MEIILQNEIP TDFYVIVSGG VDIIASKGVS EQVLAKLGPG SMAGEIGVVF 
481:	NIPQPFTVRT RRLSQVIRIG HHKFKEMVQS DNDVDAKMII ANFMTYLKGL NDELKKEIPF 
541:	LRDLLDDADA QVQETVQSEE TPQSNDEEIV TVSRHENGQI EERRREGVPK RVIIHGQAPP 
601:	NQDNKNNGDS NGRLIILPDS IQLLFDLAEK KLGKRGSTIA MADGAHVEQI DALRENDHLY 
661:	IF