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1.A.1.5.1
Cyclic nucleotide-gated (CNG) nonselective cation channel (PNa+ /PK+ ≈ 1.0)

Accession Number:P55934
Protein Name:CNG_ICTPU
Length:682
Molecular Weight:78020.00
Species:Ictalurus punctatus (Channel catfish)   [7998]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+, Na+

Cross database links:

Pfam: PF00027    PF00520   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0030552 F:cAMP binding
GO:0030553 F:cGMP binding
GO:0005216 F:ion channel activity
GO:0006811 P:ion transport
GO:0050896 P:response to stimulus
GO:0007608 P:sensory perception of smell
GO:0055085 P:transmembrane transport

References (1)

[1] “Molecular cloning and single-channel properties of the cyclic nucleotide-gated channel from catfish olfactory neurons.”  Goulding E.H.et.al.   1370374

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MTGQAALERS VSSHRLSVRS RLEGEAERAE SAISRTDGDD DTCSELQRVT ALELPSAEML 
61:	EAFTQRRPLA RLVNLVLSLR EWAHKSLVET EQRPDSFLER FRGPQAANDQ SAAPADAPKK 
121:	TFKERWEGFV VSQSDDIYYY WLFFIALASL YNWIMLVARA CFDQLQDENF FLWVGLDYLC 
181:	DVIYILDTCI RLRTGYLEQG LLVKDLAKLR DNYIRTLQFK LDFLSILPTE LLFFVTGYVP 
241:	QLRFNRLLRF SRMFEFFDRT ETRTNYPNAF RICNLILYIL VIIHWNACIY YAISKALGLS 
301:	SDTWVYSGQN KTLSFCYVYC FYWSTLTLTT IGEMPPPVKD EEYVFVVFDF LVGVLIFATI 
361:	VGNVGSMIAN MNATRAEFQT RIDAIKHYMH FRKVNRTLET RVIKWFDYLW TNKKTVDEQE 
421:	VLKNLPDKLR AEIAINVHLD TLKKVRIFQD CEAGLLVELV LKLRPQVYSP GDYICRKGDI 
481:	GKEMYIIKEG QLAVVADDGV TQFALLTAGG CFGEISILNI QGSKMGNRRT ANIRSIGYSD 
541:	LFCLSKDDLM EAVAEYPDAQ KVLEERGREI LRKQGLLDES VAAGGLGVID TEEKVERLDA 
601:	SLDILQTRFA RLLGEFTSTQ RRLKQRITAL ERQLCHTGLG LLSDNEAEGE HAGVPTHTHA 
661:	DIHAQPETHT RTSAETNSEE ET