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1.A.1.5.25
Putative cyclic AMP receptor protein (Crp), annotated in GenBank as a Crp homologue with a CAP_ED domain N-terminal and a helix-turn-hexix (HTH) domain C-terminal. This protein has two poorly hydrophobic peaks at ~ residue # 85 and 165, with a potential "P-loop" between these two peaks.  All of the cyclic nucleotide regulated channels in subfamily 2.A.1.5 have the two TMSs separated by about 80 residues with the P-loop inbetween.  Maybe the cAMP binding domains in the transcription factors and the channel proteins are derived from a common origin, and are therefore homologous.

Accession Number:D6ZSR9
Protein Name:Putative transcriptional regulator, Crp/Fnr family
Length:239
Molecular Weight:26933.00
Species:Bifidobacterium longum subsp. longum (strain JDM301) [759350]
Substrate Unknown

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  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSLETPNAFA DEENILLHTA LFKQVSPAEA EELLPHLKRA TFDKGDYIFS EGDTDQRMYL 
61:	LEQGRVKLIR TSSDDRVQLL SIHAPGEVLG EIPVFDPHGG PRTASAVSMS HGTRVVWLEH 
121:	DALFAWLDEH PRVAIDMLQV MANRQRGNNE RISDLVFMDV PARLAKTLLN LGSRFGEPVE 
181:	QGLKVPHDLT QEELAQLVGS SRETVNKALM DFSNRGWIAR DGRSIIIFQP GMLIRRSRR