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1.A.1.5.29
spHCN1 is a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel of 767 aas and 6 TMSs that opens due to inward movement of the positive charges in the fourth transmembrane domain (S4).  These channels open after only two S4s have moved, and S4 motion is rate limiting during voltage activation of spHCN channels (Bruening-Wright et al. 2007).

Accession Number:O76977
Protein Name:Hyperpolarization-activated (Ih) channel
Length:767
Molecular Weight:87938.00
Species:Strongylocentrotus purpuratus (Purple sea urchin) [7668]
Number of TMSs:6
Substrate Unknown

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDNKETNGEL EQSDEADPSG QNLDDGETDS KQEENLINVS PPKTPPGPPP PLKNGGRGQK 
61:	PPKIPICHQN GKLPKEVEWT EDRGEDRKDS LTLQSKLDHG AYTDEKQDLL TYLDRHGINS 
121:	PVKLTPDETG GSSALDILGI IEERDTGALG SDPSSTMQAM AKPVGFLQRQ LWTVLQPSDN 
181:	RLSMKLFGSK KGLQKEKYRL RKAGVLIIHP CSHFRFYWDL LMLCLIMANV ILLPVVITFF 
241:	HNKDMSTGWL IFNCFSDTFF ILDLICNFRT GIMNPKSAEQ VILNPRQIAY HYLRSWFIID 
301:	LVSSIPMDYI FLLAGGQNRH FLEVSRALKI LRFAKLLSLL RLLRLSRLMR FVSQWEQAFN 
361:	VANAVIRICN LVCMMLLIGH WNGCLQYLVP MLQEYPDQSW VAINGLEHAH WWEQYTWALF 
421:	KALSHMLCIG YGKFPPQSIT DVWLTIVSMV SGATCFALFI GHATNLIQSM DSSSRQYREK 
481:	LKQVEEYMQY RKLPSHLRNK ILDYYEYRYR GKMFDERHIF REVSESIRQD VANYNCRDLV 
541:	ASVPFFVGAD SNFVTRVVTL LEFEVFQPAD YVIQEGTFGD RMFFIQQGIV DIIMSDGVIA 
601:	TSLSDGSYFG EICLLTRERR VASVKCETYC TLFSLSVQHF NQVLDEFPAM RKTMEEIAVR 
661:	RLTRIGKESS KLKSRLESPT IRDTAPLFPI PPDTPSFVTD IEKNRFFGDD TDDVHIRTRV 
721:	DVERGSHENV IAIMDGSLSD LRMENEIQAR KSSSGKRRKF QQQTTEL