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1.A.1.5.31
Multi-domain cation channel with a C-terminal cyclic nucleotide-binding domain; of 465 aas and 6 TMS, LliK.  Cyclic nucleotide-gated (CNG) and hyperpolarization-activated cyclic nucleotide-regulated (HCN) channels play roles in phototransduction, olfaction, and cardiac pace making.  James et al. 2017 used cryoEM to determine the structure of the intact LliK CNG channel. A short S4-S5 linker connects voltage-sensing and pore domains to produce a non-domain-swapped transmembrane architecture. The conformation of the LliK structure may represent a functional state of this channel family not seen before (James et al. 2017).

Accession Number:I0XVQ9
Protein Name:Transporter, cation channel family / cyclic nucleotide-binding domain multi-domain protein
Length:434
Molecular Weight:49854.00
Species:Leptospira licerasiae serovar Varillal str. VAR 010 [1049972]
Number of TMSs:6
Substrate inorganic cations, K+

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MITLKNRIRV YWDILVFICI FWASLESPLR IVINYDPNLL LTCIYFFIDF VFALDILWNC 
61:	FTPEYKDGKW ILTRSQVIKD YLGSWFIIDL IAALPLEYAT TTIFGLQQSQ YPYLYLLLGV 
121:	TRILKVFRIS DILQRINLAF QPTPGILRLV LFAFWATLVA HWCAVGWLYV DDLLDYQTGW 
181:	SEYIIALYWT VATIATVGYG DITPSTDSQR IYTIFVMILG AGVYATVIGN IASILGSLDL 
241:	AKAAQRKKMA QVDSFLKARN ISQNIRRRVR DYYMYIIDRG WGEDENALLN DLPISLRREV 
301:	KIQLHRDLLE KVPFLKGADP ALVTSLVFSM KPMIFLEGDT IFRRGEKGDD LYILSEGSVD 
361:	ILDSDEKTIL LSLQEGQFFG ELALVMDAPR SATVRATTTC EIYTLSKTDF DNVLKRFSQF 
421:	RSAIEESVAH LKKR