TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.1.5.5
The cyclic nucleotide- and voltage-gated ion (K+, Rb+, Cs+) channel, CNGC1 (inward rectifying) (functions in heavy metal and cation transport, as does CNGC10) (Dreyer and Uozumi, 2011; Zelman et al., 2012).

Accession Number:O65717
Protein Name:Cyclic nucleotide-gated ion channel 1 aka CNGC1
Length:716
Molecular Weight:83097.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Cs+, Rb+, K+

Cross database links:

Genevestigator: O65717
eggNOG: KOG0498
HEGENOM: HBG599469
RefSeq: NP_200125.1   
Entrez Gene ID: 835393   
Pfam: PF00027    PF00520   
KEGG: ath:AT5G53130   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005516 F:calmodulin binding
GO:0030552 F:cAMP binding
GO:0030553 F:cGMP binding
GO:0005221 F:intracellular cyclic nucleotide activated c...
GO:0006816 P:calcium ion transport
GO:0006813 P:potassium ion transport
GO:0055085 P:transmembrane transport

References (6)

[1] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[2] “Characterisation of a novel gene family of putative cyclic nucleotide- and calmodulin-regulated ion channels in Arabidopsis thaliana.”  Koehler C.et.al.   10341447
[3] “Characterisation of calmodulin binding to cyclic nucleotide-gated ion channels from Arabidopsis thaliana.”  Koehler C.et.al.   10767408
[4] “Expression of a truncated tobacco NtCBP4 channel in transgenic plants and disruption of the homologous Arabidopsis CNGC1 gene confer Pb2+ tolerance.”  Sunkar R.et.al.   11115134
[5] “Phylogenetic relationships within cation transporter families of Arabidopsis.”  Maeser P.et.al.   11500563
[6] “Electrophysiological analysis of cloned cyclic nucleotide-gated ion channels.”  Leng Q.et.al.   11842144

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MNFRQEKFVR FQDWKSDKTS SDVEYSGKNE IQTGIFQRTI SSISDKFYRS FESSSARIKL 
61:	FKRSYKSYSF KEAVSKGIGS THKILDPQGP FLQRWNKIFV LACIIAVSLD PLFFYVPIID 
121:	DAKKCLGIDK KMEITASVLR SFTDVFYVLH IIFQFRTGFI APSSRVFGRG VLVEDKREIA 
181:	KRYLSSHFII DILAVLPLPQ MVILIIIPHM RGSSSLNTKN MLKFIVFFQY IPRFIRIYPL 
241:	YKEVTRTSGI LTETAWAGAA FNLFLYMLAS HVFGAFWYLF SIERETVCWK QACERNNPPC 
301:	ISKLLYCDPE TAGGNAFLNE SCPIQTPNTT LFDFGIFLDA LQSGVVESQD FPQKFFYCFW 
361:	WGLQNLSSLG QNLKTSTYIW EICFAVFISI AGLVLFSFLI GNMQTYLQST TTRLEEMRVK 
421:	RRDAEQWMSH RLLPENLRKR IRRYEQYKWQ ETRGVDEENL LSNLPKDLRR DIKRHLCLAL 
481:	LMRVPMFEKM DEQLLDALCD RLQPVLYTEE SYIVREGDPV DEMLFIMRGK LLTITTNGGR 
541:	TGFLNSEYLG AGDFCGEELL TWALDPHSSS NLPISTRTVR ALMEVEAFAL KADDLKFVAS 
601:	QFRRLHSKQL RHTFRYYSQQ WKTWAACFIQ AAWRRYIKKK LEESLKEEEN RLQDALAKEA 
661:	CGSSPSLGAT IYASRFAANI LRTIRRSGSV RKPRMPERMP PMLLQKPAEP DFNSDD