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1.A.1.5.6
The cyclic nucleotide-gated ion (K+, Rb+, Cs+) channel, CNGC2 (functions in plant defense responses, as does CNGC4) (Zelman et al., 2012).

Accession Number:O65718
Protein Name:Cyclic nucleotide-gated ion channel 2 aka CNGC2
Length:726
Molecular Weight:83241.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate K+, Rb+, Cs+

Cross database links:

Genevestigator: O65718
HEGENOM: HBG599469
RefSeq: NP_197045.1   
Entrez Gene ID: 831393   
Pfam: PF00027   
KEGG: ath:AT5G15410   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005262 F:calcium channel activity
GO:0005516 F:calmodulin binding
GO:0030552 F:cAMP binding
GO:0030553 F:cGMP binding
GO:0005222 F:intracellular cAMP activated cation channel...
GO:0005242 F:inward rectifier potassium channel activity
GO:0006811 P:ion transport
GO:0007263 P:nitric oxide mediated signal transduction
GO:0009626 P:plant-type hypersensitive response

References (8)

[1] “Cloning and first functional characterization of a plant cyclic nucleotide-gated cation channel.”  Leng Q.et.al.   10557223
[2] “The Arabidopsis dnd1 'defense, no death' gene encodes a mutated cyclic nucleotide-gated ion channel.”  Clough S.J.et.al.   10900264
[3] “Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.”  Tabata S.et.al.   11130714
[4] “Characterisation of a novel gene family of putative cyclic nucleotide- and calmodulin-regulated ion channels in Arabidopsis thaliana.”  Koehler C.et.al.   10341447
[5] “Characterisation of calmodulin binding to cyclic nucleotide-gated ion channels from Arabidopsis thaliana.”  Koehler C.et.al.   10767408
[6] “Developmentally regulated expression of a cyclic nucleotide-gated ion channel from Arabidopsis indicates its involvement in programmed cell death.”  Koehler C.et.al.   11506354
[7] “Phylogenetic relationships within cation transporter families of Arabidopsis.”  Maeser P.et.al.   11500563
[8] “A cyclic nucleotide-gated ion channel, CNGC2, is crucial for plant development and adaptation to calcium stress.”  Chan C.W.M.et.al.   12805601

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPSHPNFIFR WIGLFSDKFR RQTTGIDENS NLQINGGDSS SSGSDETPVL SSVECYACTQ 
61:	VGVPAFHSTS CDQAHAPEWR ASAGSSLVPI QEGSVPNPAR TRFRRLKGPF GEVLDPRSKR 
121:	VQRWNRALLL ARGMALAVDP LFFYALSIGR TTGPACLYMD GAFAAVVTVL RTCLDAVHLW 
181:	HVWLQFRLAY VSRESLVVGC GKLVWDPRAI ASHYARSLTG FWFDVIVILP VPQAVFWLVV 
241:	PKLIREEKVK LIMTILLLIF LFQFLPKIYH CICLMRRMQK VTGYIFGTIW WGFALNLIAY 
301:	FIASHVAGGC WYVLAIQRVA SCIRQQCMRT GNCNLSLACK EEVCYQFVSP TSTVGYPCLS 
361:	GNLTSVVNKP MCLDSNGPFR YGIYRWALPV ISSNSLAVKI LYPIFWGLMT LSTFANDLEP 
421:	TSNWLEVIFS IVMVLSGLLL FTLLIGNIQV FLHAVMAKKR KMQIRCRDME WWMKRRQLPS 
481:	RLRQRVRRFE RQRWNALGGE DELELIHDLP PGLRRDIKRY LCFDLINKVP LFRGMDDLIL 
541:	DNICDRAKPR VFSKDEKIIR EGDPVQRMIF IMRGRVKRIQ SLSKGVLATS TLEPGGYLGD 
601:	ELLSWCLRRP FLDRLPPSSA TFVCLENIEA FSLGSEDLRY ITDHFRYKFA NERLKRTARY 
661:	YSSNWRTWAA VNIQMAWRRR RKRTRGENIG GSMSPVSENS IEGNSERRLL QYAAMFMSIR 
721:	PHDHLE