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1.A.1.6.1
K+ channel, MthK or MVP of 209 aas and 6 TMSs.  Voltage-gated potassium-selective channel opened by hyperpolarization (Hellmer and Zeilinger 2003).  Mediates K+ uptake and sensitivity.  The structure and local dynamics of the closed activation gate (lower S6 region) of MVP have been reported (Randich et al. 2014).

Accession Number:Q57603
Protein Name:Y139_METJA aka MJ0139
Length:209
Molecular Weight:24183.00
Species:Methanococcus jannaschii [2190]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

HEGENOM: HBG541057
RefSeq: NP_247105.1   
Entrez Gene ID: 1450980   
Pfam: PF07885   
KEGG: mja:MJ0139   

Gene Ontology

GO:0008076 C:voltage-gated potassium channel complex
GO:0005249 F:voltage-gated potassium channel activity
GO:0006813 P:potassium ion transport

References (3)

[1] “Hyperpolarization moves S4 sensors inward to open MVP, a methanococcal voltage-gated potassium channel.”  Sesti F.et.al.   12640457
[2] “Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii.”  Bult C.J.et.al.   8688087
[3] “MjK1, a K+ channel from M. jannaschii, mediates K+ uptake and K+ sensitivity in E. coli.”  Hellmer J.et.al.   12860407

External Searches:

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  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNLKDRRLKK IMEVLSLIFT FEIVASFILS TYNPPYQDLL IKLDYISIMF FTFEFIYNFY 
61:	YVEDKAKFFK DIYNIVDAIV VIAFLLYSLQ VFYSKAFLGL RVINLLRILV LLRIIKLRKL 
121:	EENQALINFL TLLTICFIAS CLIWIVESGV NPAINNFFDA FYFTTISITT VGYGDITPKT 
181:	DAGKLIIIFS VLFFISGLIT SLQKALKGD