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1.A.1.7.1
Tok1 twin (dual) barrel outward rectifying K+ channel with exterme assymmetry which includes an extra 4 N-terminal TMSs for a total of 16 TMSs.  (Transports K+ and Cs+) (Bertl et al., 2003; Roller et al. 2008).

Accession Number:P40310
Protein Name:TOK1 aka DUK1 aka YJL093C aka J0911
Length:691
Molecular Weight:77408.00
Species:Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

Genevestigator: P40310
eggNOG: fuNOG05289
HEGENOM: HBG202178
DIP: DIP-8165N
RefSeq: NP_012442.1   
Entrez Gene ID: 853352   
Pfam: PF07885   
KEGG: sce:YJL093C   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005267 F:potassium channel activity
GO:0005244 F:voltage-gated ion channel activity
GO:0030007 P:cellular potassium ion homeostasis
GO:0006813 P:potassium ion transport

References (7)

[1] “A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem.”  Ketchum K.A.et.al.   7651518
[2] “The S. cerevisiae outwardly-rectifying potassium channel (DUK1) identifies a new family of channels with duplicated pore domains.”  Reid J.D.et.al.   8723646
[3] “A pH-sensitive yeast outward rectifier K+ channel with two pore domains and novel gating properties.”  Lesage F.et.al.   8626760
[4] “Sequence and function analysis of a 9.46 kb fragment of Saccharomyces cerevisiae chromosome X.”  Miosga T.et.al.   7985424
[5] “Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.”  Galibert F.et.al.   8641269
[6] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258
[7] “A multidimensional chromatography technology for in-depth phosphoproteome analysis.”  Albuquerque C.P.et.al.   18407956

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTRFMNSFAK QTLGYGNMAT VEQESSAQAV DSHSNNTPKQ AKGVLAEELK DALRFRDERV 
61:	SIINAEPSST LFVFWFVVSC YFPVITACLG PVANTISIAC VVEKWRSLKN NSVVTNPRSN 
121:	DTDVLMNQVK TVFDPPGIFA VNIISLVLGF TSNIILMLHF SKKLTYLKSQ LINITGWTIA 
181:	GGMLLVDVIV CSLNDMPSIY SKTIGFWFAC ISSGLYLVCT IILTIHFIGY KLGKYPPTFN 
241:	LLPNERSIMA YTVLLSLWLI WGAGMFSGLL HITYGNALYF CTVSLLTVGL GDILPKSVGA 
301:	KIMVLIFSLS GVVLMGLIVF MTRSIIQKSS GPIFFFHRVE KGRSKSWKHY MDSSKNLSER 
361:	EAFDLMKCIR QTASRKQHWF SLSVTIAIFM AFWLLGALVF KFAENWSYFN CIYFCFLCLL 
421:	TIGYGDYAPR TGAGRAFFVI WALGAVPLMG AILSTVGDLL FDISTSLDIK IGESFNNKVK 
481:	SIVFNGRQRA LSFMVNTGEI FEESDTADGD LEENTTSSQS SQISEFNDNN SEENDSGVTS 
541:	PPASLQESFS SLSKASSPEG ILPLEYVSSA EYALQDSGTC NLRNLQELLK AVKKLHRICL 
601:	ADKDYTLSFS DWSYIHKLHL RNITDIEEYT RGPEFWISPD TPLKFPLNEP HFAFMMLFKN 
661:	IEELVGNLVE DEELYKVISK RKFLGEHRKT L