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1.A.1.8.3
The 2P-domain K+ channel, TWIK 2 (functions in cell electrogenesis (Patel et al., 2000).

Accession Number:Q9Y257
Protein Name:Potassium channel subfamily K member 6 aka KCNK6
Length:313
Molecular Weight:33747.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

Genevestigator: Q9Y257
HEGENOM: HBG446730
RefSeq: NP_004814.1   
Entrez Gene ID: 9424   
Pfam: PF07885   
Drugbank: Drugbank Link   
OMIM: 603939  gene
KEGG: hsa:9424   

Gene Ontology

GO:0008076 C:voltage-gated potassium channel complex
GO:0005242 F:inward rectifier potassium channel activity
GO:0006813 P:potassium ion transport

References (4)

[1] “Identification and cloning of TWIK-originated similarity sequence (TOSS): a novel human 2-pore K+ channel principal subunit.”  Pountney D.J.et.al.   10359073
[2] “TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family.”  Chavez R.A.et.al.   10075682
[3] “TWIK-2, an inactivating 2P domain K+ channel.”  Patel A.J.et.al.   10887187
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MRRGALLAGA LAAYAAYLVL GALLVARLEG PHEARLRAEL ETLRAQLLQR SPCVAAPALD 
61:	AFVERVLAAG RLGRVVLANA SGSANASDPA WDFASALFFA STLITTVGYG YTTPLTDAGK 
121:	AFSIAFALLG VPTTMLLLTA SAQRLSLLLT HVPLSWLSMR WGWDPRRAAC WHLVALLGVV 
181:	VTVCFLVPAV IFAHLEEAWS FLDAFYFCFI SLSTIGLGDY VPGEAPGQPY RALYKVLVTV 
241:	YLFLGLVAMV LVLQTFRHVS DLHGLTELIL LPPPCPASFN ADEDDRVDIL GPQPESHQQL 
301:	SASSHTDYAS IPR