TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.1.9.2
KCNK3 K+ channel (TASK1, OAT1, TBAK1) (the K+ leak conductance). TASK1 and 3 may play a role in nontumorigenic primary hyperaldosteronism (Davies et al., 2008).  KCNK3/9/15 expression limits membrane depolarization and depolarization-induced secretion at least in part by maintaining intracellular K+ (Huang et al. 2011).

Accession Number:O14649
Protein Name:KcnK3
Length:394
Molecular Weight:43518.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

Genevestigator: O14649
eggNOG: prNOG14899
HEGENOM: HBG445489
RefSeq: NP_002237.1   
Entrez Gene ID: 3777   
Pfam: PF07885   
Drugbank: Drugbank Link   
OMIM: 603220  gene
KEGG: hsa:3777   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005267 F:potassium channel activity
GO:0005244 F:voltage-gated ion channel activity
GO:0006813 P:potassium ion transport
GO:0007268 P:synaptic transmission

References (4)

[1] “TASK, a human background K+ channel to sense external pH variations near physiological pH.”  Duprat F.et.al.   9312005
[2] “Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3.”  Lopes C.M.B.et.al.   10748056
[3] “Inhalational anesthetics activate two-pore-domain background K+ channels.”  Patel A.J.et.al.   10321245
[4] “TASK-5, a novel member of the tandem pore K+ channel family.”  Ashmole I.et.al.   11680614

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MKRQNVRTLA LIVCTFTYLL VGAAVFDALE SEPELIERQR LELRQQELRA RYNLSQGGYE 
61:	ELERVVLRLK PHKAGVQWRF AGSFYFAITV ITTIGYGHAA PSTDGGKVFC MFYALLGIPL 
121:	TLVMFQSLGE RINTLVRYLL HRAKKGLGMR RADVSMANMV LIGFFSCIST LCIGAAAFSH 
181:	YEHWTFFQAY YYCFITLTTI GFGDYVALQK DQALQTQPQY VAFSFVYILT GLTVIGAFLN 
241:	LVVLRFMTMN AEDEKRDAEH RALLTRNGQA GGGGGGGSAH TTDTASSTAA AGGGGFRNVY 
301:	AEVLHFQSMC SCLWYKSREK LQYSIPMIIP RDLSTSDTCV EQSHSSPGGG GRYSDTPSRR 
361:	CLCSGAPRSA ISSVSTGLHS LSTFRGLMKR RSSV