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1.A.1.9.5
The TWiK family muscle K+ channel protein 18 (TWiK or Two-P domain K+ channel family) (controls muscle contraction and organismal movement; Kunkel et al., 2000)

Accession Number:Q18120
Protein Name:TWiK family of potassium channels protein 18 aka twk-18
Length:461
Molecular Weight:52746.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

eggNOG: KOG1418
HEGENOM: HBG388834
RefSeq: NP_509516.1   
Entrez Gene ID: 181139   
Pfam: PF07885   
KEGG: cel:C24A3.6   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005267 F:potassium channel activity
GO:0006813 P:potassium ion transport

References (3)

[1] “Mutants of a temperature-sensitive two-P domain potassium channel.”  Kunkel M.T.et.al.   11027209
[2] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916
[3] “Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.”  Kaji H.et.al.   17761667

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAIVAQGVST ILTTFQKTFK GLLPLIILVA YTLLGAWIFW MIEGENEREM LIEQQKERDE 
61:	LIRRTVYKIN QLQIKRQRRL MTAEEEYNRT AKVLTTFQET LGIVPADMDK DIHWTFLGSI 
121:	FYCMTVYTTI GYGNIVPGTG WGRFATILYA FIGIPLTVLS LYCLGSLFAK GCKMLWRFFL 
181:	KSTRVVSKDL SNKISEAADN IEEGTTAITP SAEKTENNDD DLLSFPISGL LLITVIWVIF 
241:	CAVLFTFLEE WDFGTSLYFT LISFTTIGFG DILPSDYDFM PIVGVLLLIG LSLVSTVMTL 
301:	IQQQIEALAS GMKDNIDQEY ARALNEARED GEVDEHVDPE EDPENNKKSF DAVISRMNWS 
361:	KRGLYYLLPD SQKKELAKQS EKKMGRKSIK IQTDNDLLET LIREEILKAE LNNEMHKYTA 
421:	PRSSHQPKLV YSDVREKEVP IEVVRVEHFN HGNEDYLEHD I