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1.A.1.9.7
Sup-9 K+ channel (possibly regulated by unc-93; and may be a suppressor of unc-93. Another regulator of Sup-9 is Sup-10 (Q17374) (de la Cruz et al., 2003).

Accession Number:O17185
Protein Name:Two pore potassium channel protein sup-9
Length:329
Molecular Weight:36992.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

eggNOG: meNOG04669
HEGENOM: HBG445489
Entrez Gene ID: 173613   
Pfam: PF07885   
KEGG: cel:F34D6.3   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0055120 C:striated muscle dense body
GO:0005267 F:potassium channel activity
GO:0006937 P:regulation of muscle contraction

References (3)

[1] “sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans.”  de la Cruz I.P.et.al.   14534247
[2] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916
[3] “Evolution tunes the excitability of individual neurons.”  Salkoff L.et.al.   11301195

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKRQNIRTLS LIVCTLTYLL VGAAVFDALE TENEILQRKL VQRVREKLKT KYNMSNADYE 
61:	ILEATIVKSV PHKAGYQWKF SGAFYFATTV ITTIGYGHST PMTDAGKVFC MLYALAGIPL 
121:	GLIMFQSIGE RMNTFAAKLL RFIRRAAGKQ PIVTSSDLII FCTGWGGLLI FGGAFMFSSY 
181:	ENWTYFDAVY YCFVTLTTIG FGDYVALQKR GSLQTQPEYV FFSLVFILFG LTVISAAMNL 
241:	LVLRFLTMNT EDERRDEQEA ILAAQGLVRV GDPTADDDFG RLPLSDNVSL ASCSCYQLPD 
301:	EKLRHRHRKH TEPHGGPPTF SGMTTRPKY