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1.A.10.1.2
GIC, AMPA-subtype, GluR4 or GluR-D (preferentially monovalent cation selective)

Accession Number:P19493
Protein Name:GluR-D aka GRIA4 aka GLUR4
Length:902
Molecular Weight:100758.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2

Cross database links:

Genevestigator: P19493
eggNOG: roNOG15544
RefSeq: NP_001106655.1    NP_058959.2   
Entrez Gene ID: 29629   
Pfam: PF01094    PF00060    PF10613   
KEGG: rno:29629   

Gene Ontology

GO:0030054 C:cell junction
GO:0030425 C:dendrite
GO:0043025 C:neuronal cell body
GO:0014069 C:postsynaptic density
GO:0045211 C:postsynaptic membrane
GO:0043195 C:terminal button
GO:0004971 F:alpha-amino-3-hydroxy-5-methyl-4-isoxazole ...
GO:0005234 F:extracellular-glutamate-gated ion channel a...
GO:0006811 P:ion transport
GO:0051968 P:positive regulation of synaptic transmissio...
GO:0050803 P:regulation of synapse structure and activity

References (7)

[1] “A family of AMPA-selective glutamate receptors.”  Keinaenen K.et.al.   2166337
[2] “Cloning of a novel glutamate receptor subunit, GluR5: expression in the nervous system during development.”  Bettler B.et.al.   1977421
[3] “Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS.”  Sommer B.et.al.   1699275
[4] “Molecular cloning and development analysis of a new glutamate receptor subunit isoform in cerebellum.”  Gallo V.et.al.   1372042
[5] “Characterization of the functional role of the N-glycans in the AMPA receptor ligand-binding domain.”  Pasternack A.et.al.   12603841
[6] “Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1.”  Xia J.et.al.   10027300
[7] “Surface expression of GluR-D AMPA receptor is dependent on an interaction between its C-terminal domain and a 4.1 protein.”  Coleman S.K.et.al.   12574408
Structure:
3EN3   3EPE   3FAS   3FAT   3KEI   3KFM     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MRIICRQIVL LFSGFWGLAM GAFPSSVQIG GLFIRNTDQE YTAFRLAIFL HNTSPNASEA 
61:	PFNLVPHVDN IETANSFAVT NAFCSQYSRG VFAIFGLYDK RSVHTLTSFC SALHISLITP 
121:	SFPTEGESQF VLQLRPSLRG ALLSLLDHYE WNCFVFLYDT DRGYSILQAI MEKAGQNGWH 
181:	VSAICVENFN DVSYRQLLEE LDRRQEKKFV IDCEIERLQN ILEQIVSVGK HVKGYHYIIA 
241:	NLGFKDISLE RFIHGGANVT GFQLVDFNTP MVTKLMDRWK KLDQREYPGS ETPPKYTSAL 
301:	TYDGVLVMAE TFRSLRRQKI DISRRGNAGD CLANPAAPWG QGIDMERTLK QVRIQGLTGN 
361:	VQFDHYGRRV NYTMDVFELK STGPRKVGYW NDMDKLVLIQ DMPTLGNDTA AIENRTVVVT 
421:	TIMESPYVMY KKNHEMFEGN DKYEGYCVDL ASEIAKHIGI KYKIAIVPDG KYGARDADTK 
481:	IWNGMVGELV YGKAEIAIAP LTITLVREEV IDFSKPFMSL GISIMIKKPQ KSKPGVFSFL 
541:	DPLAYEIWMC IVFAYIGVSV VLFLVSRFSP YEWHTEEPED GKEGPSDQPP NEFGIFNSLW 
601:	FSLGAFMQQG CDISPRSLSG RIVGGVWWFF TLIIISSYTA NLAAFLTVER MVSPIESAED 
661:	LAKQTEIAYG TLDSGSTKEF FRRSKIAVYE KMWTYMRSAE PSVFTRTTAE GVARVRKSKG 
721:	KFAFLLESTM NEYTEQRKPC DTMKVGGNLD SKGYGVATPK GSSLGNAVNL AVLKLNEQGL 
781:	LDKLKNKWWY DKGECGSGGG DSKDKTSALS LSNVAGVFYI LVGGLGLAML VALIEFCYKS 
841:	RAEAKRMKLT FSEATRNKAR LSITGSVGEN GRVLTPDCPK AVHTGTAIRQ SSGLAVIASD 
901:	LP