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1.A.10.1.3
GIC, NMDA-subtype, Grin C2 (highly permeable to Ca2+ and monovalent cations). A single residue in the GluN2 subunit controls NMDA receptor channel properties via intersubunit interactions (Retchless et al., 2012). Memantine (Namenda) is prescribed as a treatment for moderate to severe Alzheimer's Disease. Memantine functions by blocking the NMDA receptor, and the sites of interaction have been identified (Limapichat et al. 2013).  Genetic mutations in multiple NMDAR subunits cause various childhood epilepsy syndromes (Li et al. 2016). NMDA receptor gating is complex, exhibiting multiple closed, open, and desensitized states, but the structure-energy landscape of gating for the rat homologue has been mapped (Dolino et al. 2017).

Accession Number:Q14957
Protein Name:GRIN2C
Length:1236
Molecular Weight:134532.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

Genevestigator: Q14957
eggNOG: prNOG13699
HEGENOM: HBG443877
RefSeq: NP_000826.2   
Entrez Gene ID: 2905   
Pfam: PF01094    PF00060    PF10565    PF00497   
OMIM: 138254  gene
KEGG: hsa:2905   

Gene Ontology

GO:0030054 C:cell junction
GO:0030288 C:outer membrane-bounded periplasmic space
GO:0045211 C:postsynaptic membrane
GO:0005234 F:extracellular-glutamate-gated ion channel a...
GO:0004972 F:N-methyl-D-aspartate selective glutamate re...
GO:0007215 P:glutamate signaling pathway
GO:0006811 P:ion transport

References (3)

[1] “Cloning of the cDNA for the human NMDA receptor NR2C subunit and its expression in the central nervous system and periphery.”  Lin Y.J.et.al.   9037519
[2] “DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.”  Zody M.C.et.al.   16625196
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MGGALGPALL LTSLFGAWAG LGPGQGEQGM TVAVVFSSSG PPQAQFRARL TPQSFLDLPL 
61:	EIQPLTVGVN TTNPSSLLTQ ICGLLGAAHV HGIVFEDNVD TEAVAQILDF ISSQTHVPIL 
121:	SISGGSAVVL TPKEPGSAFL QLGVSLEQQL QVLFKVLEEY DWSAFAVITS LHPGHALFLE 
181:	GVRAVADASH VSWRLLDVVT LELGPGGPRA RTQRLLRQLD APVFVAYCSR EEAEVLFAEA 
241:	AQAGLVGPGH VWLVPNLALG STDAPPATFP VGLISVVTES WRLSLRQKVR DGVAILALGA 
301:	HSYWRQHGTL PAPAGDCRVH PGPVSPAREA FYRHLLNVTW EGRDFSFSPG GYLVQPTMVV 
361:	IALNRHRLWE MVGRWEHGVL YMKYPVWPRY SASLQPVVDS RHLTVATLEE RPFVIVESPD 
421:	PGTGGCVPNT VPCRRQSNHT FSSGDVAPYT KLCCKGFCID ILKKLARVVK FSYDLYLVTN 
481:	GKHGKRVRGV WNGMIGEVYY KRADMAIGSL TINEERSEIV DFSVPFVETG ISVMVARSNG 
541:	TVSPSAFLEP YSPAVWVMMF VMCLTVVAIT VFMFEYFSPV SYNQNLTRGK KSGGPAFTIG 
601:	KSVWLLWALV FNNSVPIENP RGTTSKIMVL VWAFFAVIFL ASYTANLAAF MIQEQYIDTV 
661:	SGLSDKKFQR PQDQYPPFRF GTVPNGSTER NIRSNYRDMH THMVKFNQRS VEDALTSLKM 
721:	GKLDAFIYDA AVLNYMAGKD EGCKLVTIGS GKVFATTGYG IAMQKDSHWK RAIDLALLQF 
781:	LGDGETQKLE TVWLSGICQN EKNEVMSSKL DIDNMAGVFY MLLVAMGLAL LVFAWEHLVY 
841:	WKLRHSVPNS SQLDFLLAFS RGIYSCFSGV QSLASPPRQA SPDLTASSAQ ASVLKMLQAA 
901:	RDMVTTAGVS SSLDRATRTI ENWGGGRRAP PPSPCPTPRS GPSPCLPTPD PPPEPSPTGW 
961:	GPPDGGRAAL VRRAPQPPGR PPTPGPPLSD VSRVSRRPAW EARWPVRTGH CGRHLSASER 
1021:	PLSPARCHYS SFPRADRSGR PFLPLFPEPP ELEDLPLLGP EQLARREALL HAAWARGSRP 
1081:	RHASLPSSVA EAFARPSSLP AGCTGPACAR PDGHSACRRL AQAQSMCLPI YREACQEGEQ 
1141:	AGAPAWQHRQ HVCLHAHAHL PFCWGAVCPH LPPCASHGSW LSGAWGPLGH RGRTLGLGTG 
1201:	YRDSGGLDEI SRVARGTQGF PGPCTWRRIS SLESEV