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1.A.10.1.5
The homomeric cation channel/glutamate receptor/kainate 1, GluR5 (weakly responsive to glutamate) (expressed in the developing nervous system) (Bettler et al., 1990).  The 3-d structures of the protein have been determined with agonists and antagonists.  The agonist, domoic acid, stabilizes the ligand-binding core of the iGluR5 complex in a conformation that is 11 degrees more open than the conformation observed when the full agonist, (S)-glutamate, is bound (Hald et al. 2007). Kainate receptors regulate KCC2 expression in the hippocampus (Pressey et al. 2017). ().

Accession Number:P22756
Protein Name:Glutamate receptor, ionotropic kainate 1 aka GluR5 aka Grik1
Length:949
Molecular Weight:107840.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate cations

Cross database links:

Genevestigator: P22756
eggNOG: roNOG04970
DIP: DIP-29257N
RefSeq: NP_001104584.1    NP_001104587.1    NP_058937.1   
Entrez Gene ID: 29559   
Pfam: PF01094    PF00060    PF10613   
KEGG: rno:29559   

Gene Ontology

GO:0030054 C:cell junction
GO:0030425 C:dendrite
GO:0043025 C:neuronal cell body
GO:0045211 C:postsynaptic membrane
GO:0043195 C:terminal button
GO:0008144 F:drug binding
GO:0005234 F:extracellular-glutamate-gated ion channel a...
GO:0016595 F:glutamate binding
GO:0015277 F:kainate selective glutamate receptor activity
GO:0042803 F:protein homodimerization activity
GO:0022843 F:voltage-gated cation channel activity
GO:0006811 P:ion transport
GO:0035235 P:ionotropic glutamate receptor signaling pat...
GO:0032229 P:negative regulation of synaptic transmissio...
GO:0051967 P:negative regulation of synaptic transmissio...
GO:0007399 P:nervous system development
GO:0032230 P:positive regulation of synaptic transmissio...
GO:0048172 P:regulation of short-term neuronal synaptic ...

References (6)

[1] “A glutamate receptor channel with high affinity for domoate and kainate.”  Sommer B.et.al.   1373382
[2] “Cloning of a novel glutamate receptor subunit, GluR5: expression in the nervous system during development.”  Bettler B.et.al.   1977421
[3] “High-affinity kainate and domoate receptors in rat brain.”  Lomeli H.et.al.   1322826
[4] “Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate.”  Naur P.et.al.   15710405
[5] “Crystal structures of the GluR5 and GluR6 ligand binding cores: molecular mechanisms underlying kainate receptor selectivity.”  Mayer M.L.et.al.   15721240
[6] “Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists.”  Mayer M.L.et.al.   16540562
Structure:
1TXF   1VSO   1YCJ   2F34   2F35   2F36   2OJT   2PBW   2QS1   2QS2   [...more]

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MERSTVLIQP GLWTRDTSWT LLYFLCYILP QTSPQVLRIG GIFETVENEP VNVEELAFKF 
61:	AVTSINRNRT LMPNTTLTYD IQRINLFDSF EASRRACDQL ALGVAALFGP SHSSSVSAVQ 
121:	SICNALEVPH IQTRWKHPSV DSRDLFYINL YPDYAAISRA VLDLVLYYNW KTVTVVYEDS 
181:	TGLIRLQELI KAPSRYNIKI KIRQLPPANK DAKPLLKEMK KSKEFYVIFD CSHETAAEIL 
241:	KQILFMGMMT EYYHYFFTTL DLFALDLELY RYSGVNMTGF RKLNIDNPHV SSIIEKWSME 
301:	RLQAPPRPET GLLDGMMTTE AALMYDAVYM VAIASHRASQ LTVSSLQCHR HKPCALGPRF 
361:	MNLIKEARWD GLTGRITFNK TDGLRKDFDL DIISLKEEGT EKASGEVSKH LYKVWKKIGI 
421:	WNSNSGLNMT DGNRDRSNNI TDSLANRTLI VTTILEEPYV MYRKSDKPLY GNDRFEAYCL 
481:	DLLKELSNIL GFLYDVKLVP DGKYGAQNDK GEWNGMVKEL IDHRADLAVA PLTITYVREK 
541:	VIDFSKPFMT LGISILYRKP NGTNPGVFSF LNPLSPDIWM YVLLACLGVS CVLFVIARFT 
601:	PYEWYNPHPC NPDSDVVENN FTLLNSFWFG VGALMQQGSE LMPKALSTRI VGGIWWFFTL 
661:	IIISSYTANL AAFLTVERME SPIDSADDLA KQTKIEYGAV RDGSTMTFFK KSKISTYEKM 
721:	WAFMSSRQQS ALVKNSDEGI QRVLTTDYAL LMESTSIEYV TQRNCNLTQI GGLIDSKGYG 
781:	VGTPIGSPYR DKITIAILQL QEEGKLHMMK EKWWRGNGCP EEDSKEASAL GVENIGGIFI 
841:	VLAAGLVLSV FVAIGEFLYK SRKNNDVEQK GKSSRLRFYF RNKVRFHGSK KESLGVEKCL 
901:	SFNAIMEELG ISLKNQKKLK KKSRTKGKSS FTSILTCHQR RTQRKETVA