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1.A.10.1.9
The ionotropic glutamate receptor kainate 4 precursor (Glutamate receptor, KA-1 or EAA1) (Kamboj et al., 1994)

Accession Number:Q16099
Protein Name:Glutamate receptor aka KA1 aka GRIK4
Length:956
Molecular Weight:107246.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2

Cross database links:

Genevestigator: Q16099
eggNOG: prNOG08957
HEGENOM: HBG381523
RefSeq: NP_055434.2   
Entrez Gene ID: 2900   
Pfam: PF01094    PF00060    PF10613   
OMIM: 600282  gene
KEGG: hsa:2900   

Gene Ontology

GO:0030054 C:cell junction
GO:0045211 C:postsynaptic membrane
GO:0005234 F:extracellular-glutamate-gated ion channel a...
GO:0015277 F:kainate selective glutamate receptor activity
GO:0007215 P:glutamate signaling pathway
GO:0006811 P:ion transport
GO:0007268 P:synaptic transmission

References (2)

[1] “Molecular cloning, expression, and pharmacological characterization of humEAA1, a human kainate receptor subunit.”  Kamboj R.K.et.al.   8263508
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MPRVSAPLVL LPAWLVMVAC SPHSLRIAAI LDDPMECSRG ERLSITLAKN RINRAPERLG 
61:	KAKVEVDIFE LLRDSEYETA ETMCQILPKG VVAVLGPSSS PASSSIISNI CGEKEVPHFK 
121:	VAPEEFVKFQ FQRFTTLNLH PSNTDISVAV AGILNFFNCT TACLICAKAE CLLNLEKLLR 
181:	QFLISKDTLS VRMLDDTRDP TPLLKEIRDD KTATIIIHAN ASMSHTILLK AAELGMVSAY 
241:	YTYIFTNLEF SLQRMDSLVD DRVNILGFSI FNQSHAFFQE FAQSLNQSWQ ENCDHVPFTG 
301:	PALSSALLFD AVYAVVTAVQ ELNRSQEIGV KPLSCGSAQI WQHGTSLMNY LRMVELEGLT 
361:	GHIEFNSKGQ RSNYALKILQ FTRNGFRQIG QWHVAEGLSM DSHLYASNIS DTLFNTTLVV 
421:	TTILENPYLM LKGNHQEMEG NDRYEGFCVD MLKELAEILR FNYKIRLVGD GVYGVPEANG 
481:	TWTGMVGELI ARKADLAVAG LTITAEREKV IDFSKPFMTL GISILYRVHM GRKPGYFSFL 
541:	DPFSPGVWLF MLLAYLAVSC VLFLVARLTP YEWYSPHPCA QGRCNLLVNQ YSLGNSLWFP 
601:	VGGFMQQGST IAPRALSTRC VSGVWWAFTL IIISSYTANL AAFLTVQRMD VPIESVDDLA 
661:	DQTAIEYGTI HGGSSMTFFQ NSRYQTYQRM WNYMYSKQPS VFVKSTEEGI ARVLNSNYAF 
721:	LLESTMNEYY RQRNCNLTQI GGLLDTKGYG IGMPVGSVFR DEFDLAILQL QENNRLEILK 
781:	RKWWEGGKCP KEEDHRAKGL GMENIGGIFV VLICGLIVAI FMAMLEFLWT LRHSEATEVS 
841:	VCQEMVTELR SIILCQDSIH PRRRRAAVPP PRPPIPEERR PRGTATLSNG KLCGAGEPDQ 
901:	LAQRLAQEAA LVARGCTHIR VCPECRRFQG LRARPSPARS EESLEWEKTT NSSEPE