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1.A.11.4.2
Rhesus (Rh) type B glycoprotein NH3/NH4+ transporter, RhBG (~50% identical to type C) (Lopez et al., 2005; Worrell et al., 2008). Electrogenic NH4+ transport is stimulated by alkaline pH(out) but inhibited by acidic pH(out) (Nakhoul et al., 2010). Regulated by Wnt/β-catenin signalling, a pathway frequently deregulated in many cancers and associated with tumorigenesis (Merhi et al. 2015).

Accession Number:Q9H310
Protein Name:Ammonium transporter Rh type B aka RhBG
Length:441
Molecular Weight:47231.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Basolateral cell membrane1 / Multi-pass membrane protein2
Substrate ammonia, NH4+

Cross database links:

Genevestigator: Q9H310
eggNOG: prNOG09133
RefSeq: NP_065140.3   
Entrez Gene ID: 57127   
Pfam: PF00909   
OMIM: 607079  gene
KEGG: hsa:57127   

Gene Ontology

GO:0046658 C:anchored to plasma membrane
GO:0016323 C:basolateral plasma membrane
GO:0030659 C:cytoplasmic vesicle membrane
GO:0005887 C:integral to plasma membrane
GO:0014731 C:spectrin-associated cytoskeleton
GO:0051739 F:ammonia transmembrane transporter activity
GO:0008519 F:ammonium transmembrane transporter activity
GO:0030506 F:ankyrin binding
GO:0070634 P:transepithelial ammonium transport
GO:0055085 P:transmembrane transport

References (7)

[1] “Rh type B glycoprotein is a new member of the Rh superfamily and a putative ammonia transporter in mammals.”  Liu Z.et.al.   11024028
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Electroneutral ammonium transport by basolateral rhesus B glycoprotein.”  Ludewig U.et.al.   15284342
[6] “Human Rhesus B and Rhesus C glycoproteins: properties of facilitated ammonium transport in recombinant kidney cells.”  Zidi-Yahiaoui N.et.al.   15929723
[7] “The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells.”  Lopez C.et.al.   15611082

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAGSPSRAAG RRLQLPLLCL FLQGATAVLF AVFVRYNHKT DAALWHRSNH SNADNEFYFR 
61:	YPSFQDVHAM VFVGFGFLMV FLQRYGFSSV GFTFLLAAFA LQWSTLVQGF LHSFHGGHIH 
121:	VGVESMINAD FCAGAVLISF GAVLGKTGPT QLLLMALLEV VLFGINEFVL LHLLGVRDAG 
181:	GSMTIHTFGA YFGLVLSRVL YRPQLEKSKH RQGSVYHSDL FAMIGTIFLW IFWPSFNAAL 
241:	TALGAGQHRT ALNTYYSLAA STLGTFALSA LVGEDGRLDM VHIQNAALAG GVVVGTSSEM 
301:	MLTPFGALAA GFLAGTVSTL GYKFFTPILE SKFKVQDTCG VHNLHGMPGV LGALLGVLVA 
361:	GLATHEAYGD GLESVFPLIA EGQRSATSQA MHQLFGLFVT LMFASVGGGL GGLLLKLPFL 
421:	DSPPRLPALR GPSSLAGAWR A