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1.A.11.5.2
The ammonium transporter channel, AmtA (regulates NH3 homeostasis during growth and development (Yoshino et al., 2007).

Accession Number:Q9BLG4
Protein Name:AmtA
Length:463
Molecular Weight:49051.00
Species:Dictyostelium discoideum (Slime mold) [44689]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate NH4+

Cross database links:

eggNOG: KOG0682
HEGENOM: HBG677626
RefSeq: XP_642645.1   
Entrez Gene ID: 8621061   
Pfam: PF00909   
KEGG: ddi:DDB_0185017   

Gene Ontology

GO:0010008 C:endosome membrane
GO:0016021 C:integral to membrane
GO:0005765 C:lysosomal membrane
GO:0030670 C:phagocytic vesicle membrane
GO:0005886 C:plasma membrane
GO:0008519 F:ammonium transmembrane transporter activity
GO:0015696 P:ammonium transport
GO:0008283 P:cell proliferation
GO:0031159 P:positive regulation of aggregate size invol...
GO:0030587 P:sorocarp development
GO:0055085 P:transmembrane transport

References (6)

[1] “Regulation of ammonia homeostasis by the ammonium transporter AmtA in Dictyostelium discoideum.”  Yoshino R.et.al.   17951519
[2] “Sequence and analysis of chromosome 2 of Dictyostelium discoideum.”  Gloeckner G.et.al.   12097910
[3] “The genome of the social amoeba Dictyostelium discoideum.”  Eichinger L.et.al.   15875012
[4] “Temporal and spatial expression of ammonium transporter genes during growth and development of Dictyostelium discoideum.”  Follstaedt S.C.et.al.   14686953
[5] “Function of ammonium transporter A in the initiation of culmination of development in Dictyostelium discoideum.”  Singleton C.K.et.al.   16835443
[6] “Subcellular localization of ammonium transporters in Dictyostelium discoideum.”  Kirsten J.H.et.al.   19108721

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MVAGEIIKGV AAEITNGSSS SVVQKYLDCA NQVAPDPGNT TWVLLSTILV LGMMPALAFF 
61:	EAGLLRSKNT LSIITQIMSG IVVLTVMWQA FGYSLTFGPD QKGIIGNLDH AFLINVSYDD 
121:	CSPNAPNIPA AAYAFFMMMF ANITPLLMTG AFAERVKFKA FIALTVAWEI IVFYPVAHWI 
181:	WGGGWLHKYF GVLDFAGGIV IHTSAGVSAL VIALYVGRRK DFEKYGGEFP PSNLPLATIG 
241:	AALLWMGWFG FNAGSALAAG NIATSAVAST QIGGSFSAIV WIILSAAKGK PNTVSVINGV 
301:	IAGLAGITPA SGYINSQYSI GLGICLGLAS YYSVVLLKHK LHIDDALDVS SVHGLTGIIG 
361:	SLAIGFCAEL SVNPNGANGA FYGNPKLIGT QLLGVVSVAV WAAAWTWVLL KIIDATIGVK 
421:	IDESEEELGL DLVEHGEFAY HNISLQGNEN HYSSVINSHD FFK