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1.A.12.1.5
The Janus protein, CLIC2. The 3-D structure of its water soluble form has been determined at 1.8 Å resolution (Cromer et al., 2007). CLIC2 interacts with the skeletal ryanodine receptor (RyR1) and modulates its channel activity (Meng et al., 2009).

Accession Number:O15247
Protein Name:CLIC2
Length:247
Molecular Weight:28356.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Cytoplasm1 / Single-pass membrane protein2
Substrate Cl-

Cross database links:

Genevestigator: O15247
eggNOG: prNOG10884
HEGENOM: HBG444630
RefSeq: NP_001280.3   
Entrez Gene ID: 1193   
Pfam: PF00462   
OMIM: 300138  gene
KEGG: hsa:1193   

Gene Ontology

GO:0034707 C:chloride channel complex
GO:0005737 C:cytoplasm
GO:0005634 C:nucleus
GO:0009055 F:electron carrier activity
GO:0015035 F:protein disulfide oxidoreductase activity
GO:0005247 F:voltage-gated chloride channel activity
GO:0045454 P:cell redox homeostasis
GO:0006821 P:chloride transport
GO:0007165 P:signal transduction

References (9)

[1] “Genomic structure of a novel chloride channel gene, CLIC2, in Xq28.”  Heiss N.S.et.al.   9339381
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “The DNA sequence of the human X chromosome.”  Ross M.T.et.al.   15772651
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Interaction of sedlin with chloride intracellular channel proteins.”  Fan L.et.al.   12681486
[6] “CLIC-2 modulates cardiac ryanodine receptor Ca2+ release channels.”  Board P.G.et.al.   15147738
[7] “A recently identified member of the glutathione transferase structural family modifies cardiac RyR2 substate activity, coupled gating and activation by Ca2+ and ATP.”  Dulhunty A.F.et.al.   15916532
[8] “Structure of the Janus protein human CLIC2.”  Cromer B.A.et.al.   17945253
[9] “The crystal structure of human chloride intracellular channel protein 2: a disulfide bond with functional implications.”  Mi W.et.al.   18186468
Structure:
2PER   2R4V   2R5G     

External Searches:

  • Search: DB with
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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSGLRPGTQV DPEIELFVKA GSDGESIGNC PFCQRLFMIL WLKGVKFNVT TVDMTRKPEE 
61:	LKDLAPGTNP PFLVYNKELK TDFIKIEEFL EQTLAPPRYP HLSPKYKESF DVGCNLFAKF 
121:	SAYIKNTQKE ANKNFEKSLL KEFKRLDDYL NTPLLDEIDP DSAEEPPVSR RLFLDGDQLT 
181:	LADCSLLPKL NIIKVAAKKY RDFDIPAEFS GVWRYLHNAY AREEFTHTCP EDKEIENTYA 
241:	NVAKQKS