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1.A.12.1.7
Intracellular Cl- channel-3 (CLIC3). The 3-d structure is known (3FY7). This protein is associated with pregnancy disorders (Murthi et al., 2012). 

Accession Number:O95833
Protein Name:Chloride intracellular channel protein 3
Length:236
Molecular Weight:26648.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Nucleus1
Substrate Cl-

Cross database links:

Genevestigator: O95833
eggNOG: NOG325572
HEGENOM: HOG000231548
Entrez Gene ID: 9022   
KEGG: hsa:9022   

Gene Ontology

GO:0034707 C:chloride channel complex
GO:0005737 C:cytoplasm
GO:0005634 C:nucleus
GO:0005254 F:chloride channel activity
GO:0005247 F:voltage-gated chloride channel activity
GO:0007165 P:signal transduction

References (5)

[1] “DNA sequence and analysis of human chromosome 9.”  Humphray S.J.et.al.   15164053
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Molecular cloning and characterization of a mitogen-activated protein kinase-associated intracellular chloride channel.”  Qian Z.et.al.   9880541
[4] “Expression and cellular localisation of chloride intracellular channel 3 in human placenta and fetal membranes.”  Money T.T.et.al.   17027078
[5] “Structure of human CLIC3 at 2 A resolution.”  Littler D.R.et.al.   20146363
Structure:
3FY7   3KJY     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAETKLQLFV KASEDGESVG HCPSCQRLFM VLLLKGVPFT LTTVDTRRSP DVLKDFAPGS 
61:	QLPILLYDSD AKTDTLQIED FLEETLGPPD FPSLAPRYRE SNTAGNDVFH KFSAFIKNPV 
121:	PAQDEALYQQ LLRALARLDS YLRAPLEHEL AGEPQLRESR RRFLDGDRLT LADCSLLPKL 
181:	HIVDTVCAHF RQAPIPAELR GVRRYLDSAM QEKEFKYTCP HSAEILAAYR PAVHPR