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1.A.12.3.1
The bacterial CLIC homologue, stringent starvation protein A, SspA (212 aas; 0 TMSs) [N-terminal Trx domain; C-terminal glutathione S-transferase (GST) domain].  May be involved in acid (Hansen et al. 2005) and sodium ion tolerance (Wu et al. 2014).

Accession Number:P0ACA3
Protein Name:SspA
Length:212
Molecular Weight:24305.00
Species:Escherichia coli (strain K12) GN=sspA PE=1 SV=2 [83333]
Location1 / Topology2 / Orientation3: Virion1
Substrate inorganic anions (proposed), Cl-

Cross database links:

Genevestigator: P0ACA3
EchoBASE: EB0970
EcoGene: EG10977
eggNOG: COG0625
HEGENOM: HBG289890
DIP: DIP-48104N
RefSeq: AP_003771.1    NP_417696.1   
Entrez Gene ID: 944744   
Pfam: PF00043    PF02798   
BioCyc: EcoCyc:EG10977-MONOMER    ECOL168927:B3229-MONOMER   
KEGG: ecj:JW3198    eco:b3229   

Gene Ontology

GO:0006950 P:response to stress

References (5)

[1] “Structure of the gene for the stringent starvation protein of Escherichia coli.”  Serizawa H.et.al.   3029697
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.”  Link A.J.et.al.   9298646
[5] “Starvation-induced expression of SspA and SspB: the effects of a null mutation in sspA on Escherichia coli protein synthesis and survival during growth and prolonged starvation.”  Williams M.D.et.al.   8022275

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAVAANKRSV MTLFSGPTDI YSHQVRIVLA EKGVSFEIEH VEKDNPPQDL IDLNPNQSVP 
61:	TLVDRELTLW ESRIIMEYLD ERFPHPPLMP VYPVARGESR LYMHRIEKDW YTLMNTIING 
121:	SASEADAARK QLREELLAIA PVFGQKPYFL SDEFSLVDCY LAPLLWRLPQ LGIEFSGPGA 
181:	KELKGYMTRV FERDSFLASL TEAEREMRLG RS