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1.A.13.1.1
Voltage-gated bovine epithelial Cl- channel protein (Ca2+-activated), bEClC. In rats, two possible paralogues (rbCLCA1 and A2) are expressed in the CNS and peripheral organs (Yoon et al., 2006). CLCA1 may play a role in inflammatory airway diseases (Sala-Rabanal et al. 2015).

Accession Number:P54281
Protein Name:bEClC
Length:903
Molecular Weight:100306.00
Species:Bos taurus (Bovine) [9913]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Cl-

Cross database links:

eggNOG: maNOG16610
Pfam: PF08434    PF09315    PF00092   

Gene Ontology

GO:0034707 C:chloride channel complex
GO:0005262 F:calcium channel activity
GO:0005254 F:chloride channel activity
GO:0005244 F:voltage-gated ion channel activity
GO:0006816 P:calcium ion transport

References (1)

[1] “Cloning of an epithelial chloride channel from bovine trachea.”  Cunningham S.A.et.al.   8537359

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MVPRLTVILF LTLHLLPGMK SSMVNLINNG YDGIVIAINP SVPEDEKLIQ NIKEMVTEAS 
61:	TYLFHATKRR VYFRNVSILI PMTWKSKSEY LMPKQESYDQ AEVIVANPYL KHGDDPYTLQ 
121:	YGRCGEKGQY IHFTPNFLLT NNLPIYGSRG RAFVHEWAHL RWGIFDEYNG DQPFYISRRN 
181:	TIEATRCSTH ITGTNVIVKC QGGSCITRPC RRDSQTGLYE AKCTFIPEKS QTARESIMFM 
241:	QSLHSVTEFC TEKTHNVEAP NLQNKMCNGK STWDVIMNST DFQNTSPMTE MNPPTQPTFS 
301:	LLKSKQRVVC LVLDKSGSMS SEDRLFRMNQ AAELFLIQII EKGSLVGMVT FDSVAEIRNN 
361:	LTKITDDNVY ENITANLPQE ANGGTSICRG LKAGFQAIIQ SQQSTSGSEI ILLTDGEDNE 
421:	IHSCIEEVKQ SGVIIHTIAL GPSAAKELET LSDMTGGHRF YANKDINGLT NAFSRISSRS 
481:	GSITQQTIQL ESKALAITEK KWVNGTVPVD STIGNDTFFV VTWTIKKPEI LLQDPKGKKY 
541:	KTSDFKEDKL NIHSARLRIP GIAETGTWTY SLLNNHASPQ ILTVTVTTRA RSPTTPPVTA 
601:	TAHMSQNTAH YPSPVIVYAQ VSQGFLPVLG INVTAIIETE DGHQVTLELW DNGAGADTVK 
661:	NDGIYSRYFT DYRGNGRYSL KVHAEARNNT ARLSLRQPQN KALYIPGYIE NGKIILNPPR 
721:	PEVKDDLAKA EIEDFSRLTS GGSFTVSGAP PGNHPSVLPP NKIIDLEAKF KEDHIQLSWT 
781:	APANVLDKGK ANSYIIRISK SFLDLQKDFD NATLVNTSSL KPKEAGSDEN FEFKPEPFRI 
841:	ENGTNFYIAV QAINEANLTS EVSNIAQAIK FIPMPEDSVP ALGTKISAIN LAIFALAMIL 
901:	SIV