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1.A.13.1.2
Ca2+-activated Cl- channel-2, CaCC-2

Accession Number:Q14CN2
Protein Name:Calcium-activated chloride channel regulator 4
Length:919
Molecular Weight:101283.00
Species: [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cell membrane1 / Single-pass membrane protein2
Substrate Cl-

Cross database links:

Genevestigator: Q14CN2
RefSeq: NP_036260.2   
Entrez Gene ID: 22802   
Pfam: PF08434    PF09315    PF00092   
KEGG: hsa:22802   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0005576 C:extracellular region
GO:0005887 C:integral to plasma membrane
GO:0005254 F:chloride channel activity
GO:0006810 P:transport

References (8)

[1] “Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea.”  Agnel M.et.al.   10437792
[2] “The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.”  Clark H.F.et.al.   12975309
[3] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis.”  Ritzka M.et.al.   15490240
[6] “Expression and distribution of ion transport mRNAs in human nasal mucosa and nasal polyps.”  Lee S.H.et.al.   16012037
[7] “Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.”  Ramachandran P.et.al.   16740002
[8] “Transcriptomic dissection of tongue squamous cell carcinoma.”  Ye H.et.al.   18254958

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MGLFRGFVFL LVLCLLHQSN TSFIKLNNNG FEDIVIVIDP SVPEDEKIIE QIEDMVTTAS 
61:	TYLFEATEKR FFFKNVSILI PENWKENPQY KRPKHENHKH ADVIVAPPTL PGRDEPYTKQ 
121:	FTECGEKGEY IHFTPDLLLG KKQNEYGPPG KLFVHEWAHL RWGVFDEYNE DQPFYRAKSK 
181:	KIEATRCSAG ISGRNRVYKC QGGSCLSRAC RIDSTTKLYG KDCQFFPDKV QTEKASIMFM 
241:	QSIDSVVEFC NEKTHNQEAP SLQNIKCNFR STWEVISNSE DFKNTIPMVT PPPPPVFSLL 
301:	KISQRIVCLV LDKSGSMGGK DRLNRMNQAA KHFLLQTVEN GSWVGMVHFD STATIVNKLI 
361:	QIKSSDERNT LMAGLPTYPL GGTSICSGIK YAFQVIGELH SQLDGSEVLL LTDGEDNTAS 
421:	SCIDEVKQSG AIVHFIALGR AADEAVIEMS KITGGSHFYV SDEAQNNGLI DAFGALTSGN 
481:	TDLSQKSLQL ESKGLTLNSN AWMNDTVIID STVGKDTFFL ITWNSLPPSI SLWDPSGTIM 
541:	ENFTVDATSK MAYLSIPGTA KVGTWAYNLQ AKANPETLTI TVTSRAANSS VPPITVNAKM 
601:	NKDVNSFPSP MIVYAEILQG YVPVLGANVT AFIESQNGHT EVLELLDNGA GADSFKNDGV 
661:	YSRYFTAYTE NGRYSLKVRA HGGANTARLK LRPPLNRAAY IPGWVVNGEI EANPPRPEID 
721:	EDTQTTLEDF SRTASGGAFV VSQVPSLPLP DQYPPSQITD LDATVHEDKI ILTWTAPGDN 
781:	FDVGKVQRYI IRISASILDL RDSFDDALQV NTTDLSPKEA NSKESFAFKP ENISEENATH 
841:	IFIAIKSIDK SNLTSKVSNI AQVTLFIPQA NPDDIDPTPT PTPTPTPDKS HNSGVNISTL 
901:	VLSVIGSVVI VNFILSTTI