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1.A.13.1.7
xCLCA3; xCLCA2 of 942 aas and 7 TMSs.  xCLCA3 contains a predicted signal sequence, multiple sites of N-linked glycosylation, N-myristoylation, PKA, PKC, and casein kinase II phosphorylation sites, five putative hydrophobic segments, and the HExxH metalloprotease motif. Additionally, the transmembrane prediction server yielded a preserved N-terminal CLCA domain and a von Willebrand factor type A domain with one transmembrane domain in the C-terminal region (Lee and Jeong 2016). xCLCA3 is expressed in a number of tissues, with strong expression in the brain, colon, small intestine, lung, kidney, and spleen, and poor expression in the heart and liver. xCLCA3 may be a candidate CLCA family member as well as a metalloprotease, rather than just an ion channel accessory protein.

Accession Number:F7IYU5
Protein Name:Calcium activated chloride channel
Length:942
Molecular Weight:103214.00
Species:Xenopus laevis (African clawed frog) [8355]
Number of TMSs:1
Substrate Cl-

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  • 2° Structure (Network Protein Sequence Analysis)

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTFSSLFALV LTFHVFFASS TSIKLQNGGY EDIVIAINPG LRENFKIIEN IQNMIKDATP 
61:	YLFSATRNRV YIRSVKILIP ITWPNKNYTK ARTETYDKAD VIIASPHVKF GDDPYTLQYG 
121:	GCGEPGKYIH MTPDFFLDDN LISIYGPRGR VFVHEWAHLR WGVFDEYNYE KPFYVTGTKN 
181:	IEATRCSADI IGTYMKLCQG RICNCIRDPQ TGLYEDGCVF VPERNQAAKS SIMYSQALPS 
241:	VTEFCEKNHN TEAPTLQNRI CNSRSTWDVI MNSTDIKSTP PKADSNLPVP TFSLLQSSDR 
301:	VVTLVLDVSG SMTSGDRIGR LYQAAEVFVM QIVEEGSHVG IVTFSTTTAV LSKLVQVIDD 
361:	TQRNKLKRLL PKTATGGTDI CKGIREGIKL NKEHDGSSSN TELVLLTDGE DNYDTSLCFP 
421:	DIKNSGAIIH FIALGPKPAT KLEQIVEMTG GLRFLATDKV DALGLIDAFS SLKAGDGATS 
481:	QHAIQLESSG SILKPKNCLT GTVFIDKTVG NGTFFLVTWV TLVPSITLID PNGKVYTSKD 
541:	FTSDTTSKSS RLKIPGTAER GAWQYNLCNN HTANQAIGIL VTSMAADENV PPITVNAHMN 
601:	RDNNNFPEPM IVYASVNQGL LPVVNANVTA IIEPVNGKSV PLELYDNGAG VDIVKNDGIY 
661:	SGYFFEFQGN GRYSLKVRVE NSKKKSRLAL PRSRALYIPG YLENGQITMN PSRPVINDED 
721:	FYLGEFSRTA SGGSFIVNNI PPGVQPDLYK PEKVTDLEAK IEGNTIVLTW TATGDDLDKG 
781:	TVSGYDLRMN TNPSDLRNNF DNSTTVNTSS LMPQIAGSSE SFTFVPNNIA IENGTILYFA 
841:	LTAFDKVAHK SDLSNIAQAA LLIPPTPAPT TVQPLPASTT VQKTPAPTTV LPPSSDDSSG 
901:	TLDITFLTMI VCSSVIIICI IISITVCIVN CRKKKRNPEI RP