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1.A.14.2.2
The YbhL (AceP) protein. Possibly a pmf-dependent acetate uptake transporter. [14C]Acetate uptake was inhibited by CCCP as well as cold acetate, serine, α-ketoglutarate, lactate, and succinate (M. Inouye, personal communication).

Accession Number:P0AAC4
Protein Name:Inner membrane protein YbhL aka B0786
Length:234
Molecular Weight:25902.00
Species:Escherichia coli [83333]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Acetate

Cross database links:

Genevestigator: P0AAC4 P0AAC4
EchoBASE: EB3432 EB3432
EcoGene: EG13668 EG13668
eggNOG: COG0670 COG0670
HEGENOM: HBG595196 HBG595196
RefSeq: AP_001417.1    NP_415307.1   
Entrez Gene ID: 945401   
Pfam: PF01027   
BioCyc: EcoCyc:G6403-MONOMER    ECOL168927:B0786-MONOMER   
KEGG: ecj:JW0769    eco:b0786    ecj:JW0769    eco:b0786   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane

References (8)

[1] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.”  Oshima T.et.al.   8905232
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996
[5] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.”  Oshima T.et.al.   8905232
[6] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[7] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[8] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDRFPRSDSI VQPRAGLQTY MAQVYGWMTV GLLLTAFVAW YAANSAAVME LLFTNRVFLI 
61:	GLIIAQLALV IVLSAMIQKL SAGVTTMLFM LYSALTGLTL SSIFIVYTAA SIASTFVVTA 
121:	GMFGAMSLYG YTTKRDLSGF GNMLFMALIG IVLASLVNFW LKSEALMWAV TYIGVIVFVG 
181:	LTAYDTQKLK NMGEQIDTRD TSNLRKYSIL GALTLYLDFI NLFLMLLRIF GNRR