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1.A.14.3.6
Protein lifeguard 4 (LFG4), also called Golgi anti-apoptotic protein (GAAP), Protein S1R, CGI-119, Transmembrane BAX inhibitor motif-containing protein 4, (TMBIM4) and Z-protein.  Forms cation-selective ion channels. Residues that contribute to the ion-conducting pore and affect apoptosis, cell adhesion and migration independently of each other have been identified (Carrara et al. 2015).  It's functions have been reviewed (Carrara et al. 2017).

Accession Number:Q9HC24
Protein Name:Protein lifeguard 4
Length:238
Molecular Weight:26971.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate ions, inorganic cations

Cross database links:

Genevestigator: Q9HC24
eggNOG: COG0670
HEGENOM: HOG000060393
Entrez Gene ID: 51643   
Pfam: PF01027   
KEGG: hsa:51643   

Gene Ontology

GO:0005795 C:Golgi stack
GO:0016021 C:integral to membrane
GO:0006916 P:anti-apoptosis
GO:0006915 P:apoptotic process
GO:0050848 P:regulation of calcium-mediated signaling

References (8)

[1] “Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.”  Lai C.-H.et.al.   10810093
[2] “Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.”  Hu R.-M.et.al.   10931946
[3] “Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.”  Otsuki T.et.al.   16303743
[4] “The finished DNA sequence of human chromosome 12.”  Scherer S.E.et.al.   16541075
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “A new inhibitor of apoptosis from vaccinia virus and eukaryotes.”  Gubser C.et.al.   17319741
[7] “LFG: a candidate apoptosis regulatory gene family.”  Hu L.et.al.   19784873
[8] “Human Golgi antiapoptotic protein modulates intracellular calcium fluxes.”  de Mattia F.et.al.   19553469

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MADPDPRYPR SSIEDDFNYG SSVASATVHI RMAFLRKVYS ILSLQVLLTT VTSTVFLYFE 
61:	SVRTFVHESP ALILLFALGS LGLIFALILN RHKYPLNLYL LFGFTLLEAL TVAVVVTFYD 
121:	VYIILQAFIL TTTVFFGLTV YTLQSKKDFS KFGAGLFALL WILCLSGFLK FFFYSEIMEL 
181:	VLAAAGALLF CGFIIYDTHS LMHKLSPEEY VLAAISLYLD IINLFLHLLR FLEAVNKK