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1.A.16.3.1
Nitrite uptake/efflux channel (Jia et al. 2009).

Accession Number:P0AC26
Protein Name:Probable nitrite transporter NirC aka B3367
Length:268
Molecular Weight:28563.00
Species:Escherichia coli [83333]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Nitrite

Cross database links:

Genevestigator: P0AC26
EchoBASE: EB0648
EcoGene: EG10654
eggNOG: COG2116
HEGENOM: HBG726755
RefSeq: AP_004422.1    YP_026212.2   
Entrez Gene ID: 2847757   
Pfam: PF01226   
BioCyc: EcoCyc:NIRC-MONOMER    ECOL168927:B3367-MONOMER   
KEGG: ecj:JW3330    eco:b3367   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015513 F:nitrite uptake transmembrane transporter ac...
GO:0042128 P:nitrate assimilation
GO:0015707 P:nitrite transport

References (5)

[1] “Cloning of binding sequences for the Escherichia coli transcription activators, FNR and CRP: location of bases involved in discrimination between FNR and CRP.”  Bell A.I.et.al.   2543955
[2] “Nucleotide sequence, organisation and structural analysis of the products of genes in the nirB-cysG region of the Escherichia coli K-12 chromosome.”  Peakman T.et.al.   2200672
[3] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[5] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996
Structure:
4fc4     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MFTDTINKCA ANAARIARLS ANNPLGFWVS SAMAGAYVGL GIILIFTLGN LLDPSVRPLV 
61:	MGATFGIALT LVIIAGSELF TGHTMFLTFG VKAGSISHGQ MWAILPQTWL GNLVGSVFVA 
121:	MLYSWGGGSL LPVDTSIVHS VALAKTTAPA MVLFFKGALC NWLVCLAIWM ALRTEGAAKF 
181:	IAIWWCLLAF IASGYEHSIA NMTLFALSWF GNHSEAYTLA GIGHNLLWVT LGNTLSGAVF 
241:	MGLGYWYATP KANRPVADKF NQTETAAG