TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.16.4.1
Inner membrane protein, YfdC (310aas; 6 TMSs).  May be involved in surfactant resistance (Nakata et al. 2010).

Accession Number:P37327
Protein Name:Inner membrane protein yfdC
Length:310
Molecular Weight:34503.00
Species:Escherichia coli (strain K12) [83333]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate surfactants?, anions

Cross database links:

Genevestigator: P37327
EchoBASE: EB2319
EcoGene: EG12420
eggNOG: COG2116
HEGENOM: HOG000122534
Entrez Gene ID: 944801   
Pfam: PF01226   
KEGG: eco:b2347   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity

References (4)

[1] “Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features.”  Yamamoto Y.et.al.   9205837
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MDNDKIDQHS DEIEVESEEK ERGKKIEIDE DRLPSRAMAI HEHIRQDGEK ELERDAMALL 
61:	WSAIAAGLSM GASLLAKGIF QVELEGVPGS FLLENLGYTF GFIIVIMARQ QLFTENTVTA 
121:	VLPVMQKPTM SNVGLLIRLW GVVLLGNILG TGIAAWAFEY MPIFNEETRD AFVKIGMDVM 
181:	KNTPSEMFAN AIISGWLIAT MVWMFPAAGA AKIVVIILMT WLIALGDTTH IVVGSVEILY 
241:	LVFNGTLHWS DFIWPFALPT LAGNICGGTF IFALMSHAQI RNDMSNKRKA EARQKAERAE 
301:	NIKKNYKNPA