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1.A.17.1.2
Anoctamin 1, isoform b (Gnathodiaphyseal dysplasia 1 protein homologue) (39% identical to Anoctamin 1a) (Planells-Cases and Jentsch, 2009).  See also Xu et al. 2015.

Accession Number:Q75UR0
Protein Name:Anoctamin-5
Length:904
Molecular Weight:106214.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate Cl-

Cross database links:

Genevestigator: Q75UR0
eggNOG: roNOG10670
HEGENOM: HBG357842
RefSeq: NP_808362.2   
Entrez Gene ID: 233246   
Pfam: PF04547   
KEGG: mmu:233246   

Gene Ontology

GO:0034707 C:chloride channel complex
GO:0005789 C:endoplasmic reticulum membrane
GO:0005254 F:chloride channel activity
GO:0006811 P:ion transport

References (5)

[1] “The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD).”  Tsutsumi S.et.al.   15124103
[2] “Molecular cloning and characterization of the murine gnathodiaphyseal dysplasia gene GDD1.”  Tsutsumi S.et.al.   15882990
[3] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Molecular characterization of GDD1/TMEM16E, the gene product responsible for autosomal dominant gnathodiaphyseal dysplasia.”  Mizuta K.et.al.   17418107

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MVEQEGLTAK EIDYAFQQNE NLGSKETSFL IPEDLQSPPE KRFNLFLRRR LMFQRSEHSK 
61:	DSVFFRDGIR QIDFVLSYVE DLKKDGELKA ERRREFEQNL RKTGLDLETE DKLNSEDGKT 
121:	YFVKIHAPWE VLVTYAEVLG IKMPIKLSDI PRPKYPPLSY MLGAVKLPSS VKYPTPEYFT 
181:	AQFSRHRQEL FLIEDEATFF PSSTRNRIVY YILSRCPFGV EEGKKKIGIE RLLNSNTYLS 
241:	AYPLHDGQYW KPSKTTRPNE RYNLCKNWAR FSYFYKEQPF HLIRNYFGEK IGIYFVFLGY 
301:	YTEMLLFAAL VGLACFIYGL LSMENNRTST EICDPDIGGQ MIMCPLCDEV CDYWRLNTTC 
361:	LHSKFSHLFD NESTVFFALF MGIWVTLFLE FWKQRQARLE YEWDLVDFEE EQQQLQLRPE 
421:	FEAMCKHKKM NPVTKEMEPH MPLCHRIPWY FVSGTTVTFG MALLLSSMVS ILIYRLSVFA 
481:	TFASFMESEA TLQSVKSFFT PQLATALSGS CLNCIVILIL NFFYEKISAW ITKMEIPRTH 
541:	QEYESSLTLK MFLFQFVNYY SSCFYVAFFK GKFVGYPGSY TYMFNIWRSE ECGPAGCLIE 
601:	LTTQLTIIMI GKQIFGNIHE AFQPLIFNWW RRRRARTHSE KLYSRWEQDH DLQVYGHRGL 
661:	FYEYLETVIQ FGFATLFVAS FPLAPLFALM NNIMGIRVDA WKLTTQYRRP VAAKAHSIGV 
721:	WQDILFGMAI VSVATNAFIV SFTSDIIPRL VYFYAYSTNS TEPLSGYVNN SLSVFLIADF 
781:	PNHTVPMEKK DFVTCRYRDY RYPPDHEDKY SHNMQFWHVL AAKMTFIIVM EHVVFLFKFL 
841:	LAWLIPDVPK DVVEKIKREK LMTIKIIHDF ELNKLKENLD VEYGNIMKNV LVDEDNSLKA 
901:	KTTV