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1.A.17.1.22
Subdued, a calcium-activated chloride channel of 1075 aas. Functions in conjunction with the thermo-TRPs in thermal nociception. Subdued channels may amplify the nociceptive neuronal firing that is initiated by thermo-TRP channels in response to thermal stimuli (Jang et al. 2015).

Accession Number:Q9VDV4
Protein Name:Anoctamin
Length:1075
Molecular Weight:123935.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:8
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Cl-

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLNLGSAKVG ALEEATSPPP FSKDESFQLL ERSPHNPAIS PTTTVPLEPP FTTPLAPFDM 
61:	ELMKRHNLHE RLTGKESFWR GRDTSQRFLD QEQLSASRES LGAADKRARF AESNAPTLQL 
121:	PESAEPRANG KRPTGNRTNP SNPAAPLLPM TDPDFVKGNV GGVYDDRECS CPREFYQRGE 
181:	INTSLFFEDC VRSIDFVLAY RINAHEPTEL ENTEKRRVFE ANLISQGLEV ESSQKDQIWF 
241:	VKIHAPLEVL RRYAEILKLR MPMKEIPGMS VVNRSTKSVF SSLKHVFQFF LRNIYVDEEI 
301:	FPKRAHRFTA IYSRDKEYLF DIRQDCFFTT AVRSRIVEFI LDRQRFPAKN QHDMAFGIER 
361:	LIAEGVYSAA YPLHDGEITE TGTMRALLYK HWASVPKWYR YQPLDDIKEY FGVKIGLYFA 
421:	WLGYYTYMLL LASIVGVICF LYSWFSLKNY VPVKDICQSG NTNITMCPLC DWCNFWDLKE 
481:	TCNYAKVTYL IDNPSTVFFA VFMSFWATLF LELWKRYSAE ITHRWDLTGF DVHEEHPRPQ 
541:	YLARLEHIPP TRVDYVTNIK EPTVPFWRMK LPATVFSFSV VLLLIALAFV ALLAVVVYRM 
601:	SMLAALKVGA SPMTTSSAIV LATASAAFVN LCLLYILNYM YNHLAEYLTE LEMWRTQTQF 
661:	DDSLTLKIYL LQFVNYYASI FYIAFFKGKF VGHPGEYNKL FDYRQEECSS GGCLTELCIQ 
721:	LAIIMVGKQA FNTILEVYLP MFWRKVLAIQ VGLSRLFNNT PNPDKAKDER WMRDFKLLDW 
781:	GARGLFPEYL EMVLQYGFVT IFVAAFPLAP FFALLNNILE MRLDAKKLLT HHKRPVSQRV 
841:	RDIGVWYRIL DCIGKLSVIT NGFIIAFTSD MIPRLVYRHY VNKQGTLDGY LNFTLSEFKV 
901:	IDSPTLYSLA GDLSNITTCR YTDFRLPPSS PEKYTLSSMF YIILACRLGF VVVFENFVAL 
961:	VMILVRWCIP DMSVELRDQI RREVYVTNEI IIDQEAHRAR FERAKRSSSV LQTPVDQDMD 
1021:	AASIQEPNAK FINIEKLLTE NLTQIEMDAI IHGENPITGI SGADCLDEVH KKLSD