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1.A.17.4.1
TMC2, like TMC1, plays a role in hearing and gravity detection (Kawashima et al., 2011).  Required for normal function of cochlear hair cells, possibly as a Ca2+ channel (Kim and Fettiplace 2013).  TMC1 and TMC2 are both components of hair cell transduction channels and contribute to permeation properties (Pan et al. 2013; Kawashima et al. 2014).  Both TMC1 and 2 interact with Protocadherin 15 (Maeda et al. 2014). TMC1 and TMC2 are components of the stereocilia mechanoelectrical transduction channel complex (Kurima et al. 2015). While TMC2 is required for mechanotransduction in mature vestibular hair cells, its expression in the immature cochlea may be an evolutionary remnant (Corns et al. 2017).

Accession Number:Q8R4P4
Protein Name:Transmembrane channel-like protein 2
Length:888
Molecular Weight:101134.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Ca2+

Cross database links:

Genevestigator: Q8R4P4
HEGENOM: HBG716626
Entrez Gene ID: 192140   
Pfam: PF07810   
KEGG: mmu:192140   

Gene Ontology

GO:0016021 C:integral to membrane

References (2)

[1] “Dominant and recessive deafness caused by mutations of a novel gene, TMC1, required for cochlear hair-cell function.”  Kurima K.et.al.   11850618
[2] “TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins.”  Keresztes G.et.al.   12812529

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSPQLKSLDE EGDKSARRPT RKQTSRAACP QDGHRAQSSR KDPAKGSPRP GSSRKKQMEH 
61:	GSYHKGLQGQ KPRKVERSLQ GRKKDRRTSL KEQRASPKKE REALRKEAGK QLRKPRSTSL 
121:	GSSVSTGDSL SEEELAQILE QVEEKKKLIT TVRNKPWPMA KKLRELREAQ AFVEKYEGAL 
181:	GKGKGKHLYA YRMMMAKKWV KFKRDFDNFK TQCIPWEMKI KDIESHFGSS VASYFIFLRW 
241:	MYGVNLVLFG LIFGLVIIPE VLMGMPYGSI PRKTVPRAEE ERAMDFSVLW DFEGYIKYSA 
301:	LFYGYYNNQR TIGWLRYRLP MAYFMVGVSV FGYSLMIVIR SMASNTQGST SEGDSDSFTF 
361:	SFKMFTSWDY LIGNSETADN KYVSITTSFK ESIVDEQESN KEGNIHLTRF LRVLANFLIL 
421:	CCLCGSGYLI YFVVKRSQEF SKMQNVSWYE RNEVEIVMSL LGMFCPPLFE TIAALENYHP 
481:	RTGLKWQLGR IFALFLGNLY TFLLALMDDV HLKLSNEEKI KNITHWTLFN YYNSSGGNES 
541:	VPRPPPHPAD VPRGSCWETA VGIEFMRLTV SDMLVTYLTI LVGDFLRACF VRFMNHCWCW 
601:	DLEAGFPSYA EFDISGNVLG LIFNQGMIWM GSFYAPGLVG INVLRLLTSM YFQCWAVMSS 
661:	NVPHERVFKA SRSNNFYMGL LLLVLFLSLL PVAYTVMSLP PSFDCGPFSG KNRMYDVLHE 
721:	TIENDFPKFL GKIFAFLANP GLIIPAILLM FLAIYYLNSV SKSLSRANAQ LRKKIQALRE 
781:	VEKNHKSIKG KAIVTYSEDT IKNSSKNATQ IHLTKEEPTS HSSSQIQTLD KKAQGPHTSS 
841:	TEGGASPSTS WHHVGSQPPR GRRDSGQPQS QTYTGRSPSG KRTQRPHN