TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.17.4.2
Transmembrane channel-like protein-B, Tmc8 (EVER2).  Occurs in the endoplasmic reticulum where it functions to release Ca2+ and Zn2+ and supresses Cl- currents (Sirianant et al. 2014). 

Accession Number:Q7TN58
Protein Name:Transmembrane channel-like protein 8
Length:722
Molecular Weight:82329.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate Ca2+, Zn2+

Cross database links:

Genevestigator: Q7TN58
eggNOG: NOG70493
Entrez Gene ID: 217356   
Pfam: PF07810   
KEGG: mmu:217356   

Gene Ontology

GO:0005789 C:endoplasmic reticulum membrane
GO:0016021 C:integral to membrane

References (3)

[1] “Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis.”  Kurima K.et.al.   12906855
[2] “TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins.”  Keresztes G.et.al.   12812529
[3] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MFRQWSVQSG PAPRRPESQA ASEELWEQEV ERLCASRTPV RMLPYAMADK RFIRELREPE 
61:	GVKTTFWQRW HRPRRVARQH LREAEQRLAR GFGLWEGALY EIGGLFGTGI QSYFTFLRFL 
121:	LLLNLLTMLL TACFVLLPLV WLRPPELGPA LKLRLQCSSS PLPQSDIPRF HNPLWNILTG 
181:	RAFNNTYLFY GAYRAGPESS SEYSIRLAYL LSPMVCLLLC FCGILQRMAE GLPQQTLLGQ 
241:	RYRTPLSAKV FSSWDFCIRV WEAATIKKHE ISNELKMELE EGRRVELAQQ QTRAQKACRL 
301:	LTYLRTNILI VLLVVGAISA IFWATKYSQD NKEESLFLVL QYLPPGVISL VNFLGPQLFT 
361:	VLIQLENYPP GTEVNLTLIW CVVLKLASLG MFSFSLGQTV LCIGRNKTSC ESYGYNACDY 
421:	QCWENSVGEE LYKLIIFNFL LTVAFAFLVS LPRRLLVERF SGWFWTWLDR EEFLVPKNVL 
481:	DIVAAQTVTW MGLFYCPLLP LLNSVFLFLT FYIKKYTLLR NSRASPRRFR ASSSTFFFHL 
541:	VLLLGLLLAA VPLAYVISST HSSWDCGLFT NYSAPWQVVP ELVALQLPLP SQRALRYLSS 
601:	HAFSFPLLIL LSIVLTVCIS QSRANARAIQ GLRKQLVWQV QEKWHLVDDL SRLLPELSPE 
661:	PGSPHSRASR PRSFCPGFPC PGSPGPRTPR LAPSNRLSSS SLGAPSASVP ASRFHFPSRT 
721:	EL