TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.17.4.7
The sodium sensor/cation conductance channel activated by high extracellular Na+, Tmc-1 (Tmc1) (Chatzigeorgiou et al. 2013).  It functions in salt taste chemosensation and salt avoidance and is an ionotropic sensory receptor.  Wang et al. 2016 showed that C. elegans TMC-1 mediates nociceptor responses to high pH, not sodium, allowing the nematode to avoid strongly alkaline environments in which most animals cannot survive (Spalthoff and Göpfert 2016).  TMC-1 and TMC-2 are required for normal egg laying in C. elegans. Mutations in these proteins cause membrane hyperpolarization and disrupt the rhythmic calcium activities in both neurons and muscles involved in egg laying. Mechanistically, TMC proteins enhance membrane depolarization through background leak currents, and ectopic expression of both C. elegans and mammalian TMC proteins results in membrane depolarization (Yue et al. 2018).

Accession Number:D3KZG3
Protein Name:Protein TMC-1
Length:1285
Molecular Weight:147129.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:8
Substrate Na+

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MQEAARRASL RKEHTPTNEK FGDLSKQDSL GERASSKLTL DDELYDILYA FGETDAFINK 
61:	GDKQRETDED GNPLTRQALL ERIRQKKEVI GKLRCQAWSM TRKRRTLKLA QKYLEQHESK 
121:	VSRSHLYMEE MRKRARLMKR SFSNFKTYLI PWESKIKRIE SHFGSVVSSY FTFLRWIVFV 
181:	NIMITLIALV FVVLPETLAD SVANEGRFNR TKTRKQIPAN ERVHADELAV VWHYDGYLRY 
241:	SPLFYGYYSD DPFLGNKIKY ALPLAYFMVT LTIFAYSFFA ILRKMAANAR MSKLSGSKAE 
301:	QYIFNWKLFT GWDYTIGNSE TASNTVMAVV IKLRESIADI KKDAHGKFRL LQFSLRVFAN 
361:	IIICAMLGFS IYCIIFAVQK SQVQDDGNLF TKNQVPSVVS TITHVFPMIF DLIGKMENYH 
421:	PRTALRAHLG RVLILYTVNY ITLIFALFEK MTALRDRVNS TSTSSSHRTK RQQGGWNPNM 
481:	QRPPPYASRA EVRQMSDFLA ANTRRFQTVS QRTTRSVTTP FTVAPQFGPF NVNNPNAVFH 
541:	NGTHSTSFES QILGPKALPI FTPPPRKYPG FTPGNVGQQF GGPDFPRNQV YTKSTPLPRV 
601:	RTKPPWVYTT THPPLVQNRA MTTTMSKSAK KGNSKNLDDD ILLSNETIQM SEAALRRNHD 
661:	GHNNDICWET IIGQEIVKLV TMDLIFTILS ILVIDLFRGL WIKYCSSWWC WDIETTFPEY 
721:	GEFKVAENVL HIINNQGMIW LGLFFAPLLP AINNIKLIIL MYIRGWAVMT CNVPAREIFR 
781:	ASRSSNFYLG ILLIWLLLCT LPVGFVIASM SPSRSCGPFA RYQHFYTVVT REIEKRVDQT 
841:	VLSYIRHIAS PGVVIPIILF LILIIYFLFS LVRGLREANT DLQAQLVHER TEEKKKIFEL 
901:	AGGKKNKFEK DRDKKRSNDY IPLIEQRRRE PWRQYHEMEA DHALASDSSE ESDINEDEDD 
961:	ERQPLTAYPL RAIETPPETL QVTAFHPSLG SLIENREMED EESASGDQLP MIHKSVSFQG 
1021:	PSHMQMRQSI STESCSQISR SAIQVATPEE IRALLRPYLE AKYGIPYQHG IKSFPIDVHT 
1081:	PPNNTPSRRS SKYNSFVSLY EHTRDDHKNF VASTIKETDE DPGKSDKKQT SSKDVAPDFM 
1141:	PWPSADEARA LREKMKSKTP LMLTKTTVEE KPKGGKSSES EFRPPVPIHR KYNIQTTEEE 
1201:	NEEEETDSAP ESSKKRFRIS VSPTKTIAPA SASRAQHKIV SQASSSSSIP HGRQPDPNKK 
1261:	ASLVLPPLRA PRVQFDEDDS PRQID