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1.A.17.4.7
The sodium sensor/cation conductance channel activated by high extracellular Na+, Tmc-1 (Tmc1) (Chatzigeorgiou et al. 2013).  It functions in salt taste chemosensation and salt avoidance and is an ionotropic sensory receptor.  Wang et al. 2016 showed that C. elegans TMC-1 mediates nociceptor responses to high pH, not sodium, allowing the nematode to avoid strongly alkaline environments in which most animals cannot survive (Spalthoff and Göpfert 2016).

Accession Number:D3KZG3
Protein Name:Protein TMC-1
Length:1285
Molecular Weight:147129.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:8
Substrate Na+

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MQEAARRASL RKEHTPTNEK FGDLSKQDSL GERASSKLTL DDELYDILYA FGETDAFINK 
61:	GDKQRETDED GNPLTRQALL ERIRQKKEVI GKLRCQAWSM TRKRRTLKLA QKYLEQHESK 
121:	VSRSHLYMEE MRKRARLMKR SFSNFKTYLI PWESKIKRIE SHFGSVVSSY FTFLRWIVFV 
181:	NIMITLIALV FVVLPETLAD SVANEGRFNR TKTRKQIPAN ERVHADELAV VWHYDGYLRY 
241:	SPLFYGYYSD DPFLGNKIKY ALPLAYFMVT LTIFAYSFFA ILRKMAANAR MSKLSGSKAE 
301:	QYIFNWKLFT GWDYTIGNSE TASNTVMAVV IKLRESIADI KKDAHGKFRL LQFSLRVFAN 
361:	IIICAMLGFS IYCIIFAVQK SQVQDDGNLF TKNQVPSVVS TITHVFPMIF DLIGKMENYH 
421:	PRTALRAHLG RVLILYTVNY ITLIFALFEK MTALRDRVNS TSTSSSHRTK RQQGGWNPNM 
481:	QRPPPYASRA EVRQMSDFLA ANTRRFQTVS QRTTRSVTTP FTVAPQFGPF NVNNPNAVFH 
541:	NGTHSTSFES QILGPKALPI FTPPPRKYPG FTPGNVGQQF GGPDFPRNQV YTKSTPLPRV 
601:	RTKPPWVYTT THPPLVQNRA MTTTMSKSAK KGNSKNLDDD ILLSNETIQM SEAALRRNHD 
661:	GHNNDICWET IIGQEIVKLV TMDLIFTILS ILVIDLFRGL WIKYCSSWWC WDIETTFPEY 
721:	GEFKVAENVL HIINNQGMIW LGLFFAPLLP AINNIKLIIL MYIRGWAVMT CNVPAREIFR 
781:	ASRSSNFYLG ILLIWLLLCT LPVGFVIASM SPSRSCGPFA RYQHFYTVVT REIEKRVDQT 
841:	VLSYIRHIAS PGVVIPIILF LILIIYFLFS LVRGLREANT DLQAQLVHER TEEKKKIFEL 
901:	AGGKKNKFEK DRDKKRSNDY IPLIEQRRRE PWRQYHEMEA DHALASDSSE ESDINEDEDD 
961:	ERQPLTAYPL RAIETPPETL QVTAFHPSLG SLIENREMED EESASGDQLP MIHKSVSFQG 
1021:	PSHMQMRQSI STESCSQISR SAIQVATPEE IRALLRPYLE AKYGIPYQHG IKSFPIDVHT 
1081:	PPNNTPSRRS SKYNSFVSLY EHTRDDHKNF VASTIKETDE DPGKSDKKQT SSKDVAPDFM 
1141:	PWPSADEARA LREKMKSKTP LMLTKTTVEE KPKGGKSSES EFRPPVPIHR KYNIQTTEEE 
1201:	NEEEETDSAP ESSKKRFRIS VSPTKTIAPA SASRAQHKIV SQASSSSSIP HGRQPDPNKK 
1261:	ASLVLPPLRA PRVQFDEDDS PRQID