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1.A.17.4.8
Tmc2 channel of 1203 aas and 9 - 11 TMSs; functions in touch neurons as a mechanosensitive touch sensor (Chatzigeorgiou et al. 2013; WR Schafer, personal communication).  May function as a Na+/K+ channel.  TMC-1 and TMC-2 are required for normal egg laying in C. elegans. Mutations in these proteins cause membrane hyperpolarization and disrupt the rhythmic calcium activities in both neurons and muscles involved in egg laying. Mechanistically, TMC proteins enhance membrane depolarization through background leak currents, and ectopic expression of both C. elegans and mammalian TMC proteins results in membrane depolarization (Yue et al. 2018).

Accession Number:Q11069
Protein Name:Transmembrane channel-like protein 2
Length:1203
Molecular Weight:136060.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Na+, K+

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MPKSGAHQPL VRHDTDDGGE TGQSVKSLAD VSEEEIDSRM SRRSSVIADL LSLFRRSSSV 
61:	LVRPHTRLGN PNFDDDDDEF DEEDDKEASK DRILKKIQQK KEIIQKLRGQ PWYMKRKRRT 
121:	LKVAQKHLQQ QEAKVSKARL YKAEAGRRLT QASRWLDNLK IYLIPWEAKI RKIESHFGSV 
181:	VSSYFTFHRW VLGVNITITF IMCMFVVIPE WLADSRTQFG DDRYNKTKAI KVMPPAVRAR 
241:	ADELSTVWDF GGYFQYSLLF YGFYSKETFF GETIKYRVPV AYFFCNIFIL GFSLFIILRK 
301:	MAANNRRGTL SSGKTQQYLF NWKAFTGWDY TIGNPETAGN VYMANVIKFR EAINDDKQKP 
361:	SDKHPWIRFV ARVLTNLFIC AMYVFSIWAI MQCGTLKGEH FFAQNATAIT ISLITLVFPN 
421:	IFDLLGKIEK LHPRNALRFQ LGRVLVLYIL NYYTLIYSLM LQLEHLQKEK NASDNPISAL 
481:	GHPGDAIGRT IRETVLPRYP VDNNPHTYYS YAPVTTTPIP ATSSWTTVLP DFGPFGVYNP 
541:	KASVTKDDTV FSSPVVETHM FGPNSDWNET TVNAASPTGA TTRASLRMSQ GGLCWETIIG 
601:	QEITKLVTMD LYMTVASIFL IDFLRGLACR YLNLYWPWDL ERTFPEYGEF KVAENVLHLV 
661:	NNQGMIWLGL FFVPLLPMLN NIKLIILMYI RGWAAMTCNV PASQIFRASR SSNFFFALLI 
721:	LFLFLCTLPV GFVIASKTPS KSCGPFGNQS FFYSVITDVL HENLDKTLVN GIKYSLSPGI 
781:	IIPVLVLLSL VIYFLIAMVT GLSQANQDLS FQLMVERTEE KKKIFELAGG KKKKSKDNTF 
841:	GKQKPKQLLP PPTKGVSSDD DSQHNRSTAK SVSGRQFVPS LGSVSEVDHS TGEEQSSDSE 
901:	STTSSLPPKL SLRQRFLVCI GWADPNKYGR HDDIEMEEGG GRLRELSTGS ETDSDDEDSE 
961:	KSNRDMSYRT AIQSFDQNSQ SASASSSKST TTAPSNSEMR IEITENPLHT YITPLRIEKK 
1021:	SSASSSSSSH QPSSSIEKQA ARRLLQPIST THNIRYGVAT VENSSQDPTR PPSTDDSLGD 
1081:	PALHEPLWAN LNPHSSYTSA MMSPIMNEVM SNDETTDDEK GRLIPDRPPI PHSPRELKRL 
1141:	KREKDQQSES GSKPSTPRPP RFRISMSPPR KPPSEKNDSD SSNRKYEMRV EKSPKKPKKS 
1201:	DND