TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.17.5.10
The non-rectifying, plasma membrane, calcium-permeable, stress-gated, cation channel 1 (CSC1) of 771 aas (Hou et al. 2014).  Activated by hyperosmotic shock.  Permeable to Ca2+, K+ and Na+.  Inactivation or closure is Ca2+-dependent.  The N-terminal region contains 3 TMSs, the first of which may be a cleavable signal peptide., and the C-terminal region contains 6 TMSs corresponding to the DUF221 domain.  Arabidopsis contains at least 15 CSCs ((Hou et al. 2014).  Some plant homologues are transcriptionally upregulated in response to vaious abiotic and biotic stresses involving mechanical perturbation (Kiyosue et al. 1994).

Accession Number:Q5XEZ5
Protein Name:Calcium permeable stress-gated cation channel 1
Length:771
Molecular Weight:87894.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+, Na+, Ca2+

Cross database links:

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MATLQDIGVS AGINILSAFV FFIIFAVLRL QPFNDRVYFS KWYLKGLRSS PARGGAFAQR 
61:	FVNLDFRSYM KFLNWMPEAL KMPEPELIDH AGLDSVVYLR IYWLGLKIFT PIAVLAWAVL 
121:	VPVNWTNNTL EMAKQLRNVT SSDIDKLSVS NIPEYSMRFW THIVMAYAFT IWTCYVLMKE 
181:	YETIANMRLQ FVASEARRPD QFTVLVRNVP PDADESVSEL VEHFFLVNHP DHYLTHQVVC 
241:	NANKLADLVK KKKKLQNWLD YYQLKYARNN SQRIMVKLGF LGLWGQKVDA IEHYIAEIDK 
301:	ISKEISKERE EVVNDPKAIM PAAFVSFKTR WAAAVCAQTQ QTRNPTQWLT EWAPEPRDVF 
361:	WSNLAIPYVS LTVRRLIMHV AFFFLTFFFI VPIAFVQSLA TIEGIVKAAP FLKFIVDDKF 
421:	MKSVIQGFLP GIALKLFLAF LPSILMIMSK FEGFTSISSL ERRAAFRYYI FNLVNVFLAS 
481:	VIAGAAFEQL NSFLNQSANQ IPKTIGVAIP MKATFFITYI MVDGWAGVAG EILMLKPLIM 
541:	FHLKNAFLVK TDKDREEAMD PGSIGFNTGE PRIQLYFLLG LVYAPVTPML LPFILVFFAL 
601:	AYIVYRHQII NVYNQEYESA AAFWPDVHGR VIAALVISQL LLMGLLGTKH AALAAPFLIA 
661:	LPVLTIGFHH FCKGRYEPAF IRYPLQEAMM KDTLETAREP NLNLKGYLQN AYVHPVFKGD 
721:	EDDYDIDDKL GKFEDEAIIV PTKRQSRRNT PAPSIISGDD SPSLPFSGKL V