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1.A.19.1.2
Matrix protein M2 of 96 aas and 1 TMS.  Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into the virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway.

Accession Number:U5N0S1
Protein Name:Matrix protein 2
Length:96
Molecular Weight:11418.00
Species:Influenza A virus (A/flat-faced bat/Peru/033/2010(H18N11)) [1395524]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Virion membrane1
Substrate H+

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FASTA formatted sequence
1:	MSILTEVETL TRKGWESRCS GLNEDLILAA NIIGIIHLAL WIIDRWLYRY SLLIYRKIWN 
61:	TWGLKPVDST KELREEFKEE HKSIEFPDPI MTIIEN