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1.A.2.1.10
G-protein-activated inward rectifying K+ channel, Kir3.2 or GIRK (Inanobe et al., 2011; Yokogawa et al. 2011).  Important in regulating heart rate and neuronal excitability.  Activated by binding of the βγ-subunit complex to the cytoplasmic pore gate (Yokogawa et al. 2011). Chen et al. 2017 found that the G-protein-gated inwardly rectifying K+ (GIRK) channel is activated by IVM directly.

Accession Number:P48051
Protein Name:G protein-activated inward rectifier potassium channel 2
Length:423
Molecular Weight:48451.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

Genevestigator: P48051
eggNOG: prNOG19724
HEGENOM: HBG716702
Entrez Gene ID: 3763   
Pfam: PF01007   
Drugbank: Drugbank Link   
KEGG: hsa:3763   

Gene Ontology

GO:0005794 C:Golgi apparatus
GO:0008076 C:voltage-gated potassium channel complex
GO:0015467 F:G-protein activated inward rectifier potassium channel activity
GO:0007268 P:synaptic transmission

References (5)

[1] “Pancreatic islet cells express a family of inwardly rectifying K+ channel subunits which interact to form G-protein-activated channels.”  Ferrer J.et.al.   7592809
[2] “Co-expression of human Kir3 subunits can yield channels with different functional properties.”  Schoots O.et.al.   10659995
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Characterization and variation of a human inwardly-rectifying-K-channel gene (KCNJ6): a putative ATP-sensitive K-channel subunit.”  Sakura H.et.al.   7796919
[5] “Isolation of a cDNA clone encoding a KATP channel-like protein expressed in insulin-secreting cells, localization of the human gene to chromosome band 21q22.1, and linkage studies with NIDDM.”  Tsaur M.-L.et.al.   7729621
Structure:
3sya   3syc   3syp     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAKLTESMTN VLEGDSMDQD VESPVAIHQP KLPKQARDDL PRHISRDRTK RKIQRYVRKD 
61:	GKCNVHHGNV RETYRYLTDI FTTLVDLKWR FNLLIFVMVY TVTWLFFGMI WWLIAYIRGD 
121:	MDHIEDPSWT PCVTNLNGFV SAFLFSIETE TTIGYGYRVI TDKCPEGIIL LLIQSVLGSI 
181:	VNAFMVGCMF VKISQPKKRA ETLVFSTHAV ISMRDGKLCL MFRVGDLRNS HIVEASIRAK 
241:	LIKSKQTSEG EFIPLNQTDI NVGYYTGDDR LFLVSPLIIS HEINQQSPFW EISKAQLPKE 
301:	ELEIVVILEG MVEATGMTCQ ARSSYITSEI LWGYRFTPVL TLEDGFYEVD YNSFHETYET 
361:	STPSLSAKEL AELASRAELP LSWSVSSKLN QHAELETEEE EKNLEEQTER NGDVANLENE 
421:	SKV