TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.2.1.11
Inward rectifying potassium channel 16, Kir5.1. (Potassium channel subfamily J member 16), KCNJ16.  Involved in pH and fluid regulation.  Forms heteromers with Kir4.1/KCNJ10 or Kir2.1/KCNJ2.

Accession Number:Q9NPI9
Protein Name:Inward rectifier potassium channel 16
Length:418
Molecular Weight:47949.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

Genevestigator: Q9NPI9
eggNOG: NOG277052
HEGENOM: HOG000237325
Entrez Gene ID: 3773   
Pfam: PF01007   
KEGG: hsa:3773   

Gene Ontology

GO:0008076 C:voltage-gated potassium channel complex
GO:0005242 F:inward rectifier potassium channel activity
GO:0007268 P:synaptic transmission

References (2)

[1] “The human inward rectifier K(+) channel subunit kir5.1 (KCNJ16) maps to chromosome 17q25 and is expressed in kidney and pancreas.”  Liu Y.et.al.   11060447
[2] “Genetic and functional linkage of Kir5.1 and Kir2.1 channel subunits.”  Derst C.et.al.   11240146

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MSYYGSSYHI INADAKYPGY PPEHIIAEKR RARRRLLHKD GSCNVYFKHI FGEWGSYVVD 
61:	IFTTLVDTKW RHMFVIFSLS YILSWLIFGS VFWLIAFHHG DLLNDPDITP CVDNVHSFTG 
121:	AFLFSLETQT TIGYGYRCVT EECSVAVLMV ILQSILSCII NTFIIGAALA KMATARKRAQ 
181:	TIRFSYFALI GMRDGKLCLM WRIGDFRPNH VVEGTVRAQL LRYTEDSEGR MTMAFKDLKL 
241:	VNDQIILVTP VTIVHEIDHE SPLYALDRKA VAKDNFEILV TFIYTGDSTG TSHQSRSSYV 
301:	PREILWGHRF NDVLEVKRKY YKVNCLQFEG SVEVYAPFCS AKQLDWKDQQ LHIEKAPPVR 
361:	ESCTSDTKAR RRSFSAVAIV SSCENPEETT TSATHEYRET PYQKALLTLN RISVESQM