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1.A.2.1.3
G-protein activated IRK5 channel. The p75 neurotrophin receptor mediates cell death by activating GIRK channels through phosphatidylinositol 4,5-bisphosphate (Coulson et al., 2008). Cholesterol up-regulates neuronal GIRK channel activity (Bukiya et al. 2017).

Accession Number:P48544
Protein Name:IRK5 aka GIRK4 aka KCNJ5
Length:419
Molecular Weight:47668.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

Genevestigator: P48544
eggNOG: prNOG04147
HEGENOM: HBG716702
RefSeq: NP_000881.3   
Entrez Gene ID: 3762   
Pfam: PF01007   
OMIM: 600734  gene
KEGG: hsa:3762   

Gene Ontology

GO:0008076 C:voltage-gated potassium channel complex
GO:0015467 F:G-protein activated inward rectifier potass...
GO:0005515 F:protein binding
GO:0006813 P:potassium ion transport

References (7)

[1] “Cloning and functional expression of a rat heart KATP channel.”  Ashford M.L.J.et.al.   8047164
[2] “”  Ashford M.L.J.et.al.   8524415
[3] “A G-protein-activated inwardly rectifying K+ channel (GIRK4) from human hippocampus associates with other GIRK channels.”  Spauschus A.et.al.   8558261
[4] “Co-expression of human Kir3 subunits can yield channels with different functional properties.”  Schoots O.et.al.   10659995
[5] “Functional characterization and localization of a cardiac-type inwardly rectifying K+ channel.”  Iizuka M.et.al.   8834003
[6] “Human chromosome 11 DNA sequence and analysis including novel gene identification.”  Taylor T.D.et.al.   16554811
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAGDSRNAMN QDMEIGVTPW DPKKIPKQAR DYVPIATDRT RLLAEGKKPR QRYMEKSGKC 
61:	NVHHGNVQET YRYLSDLFTT LVDLKWRFNL LVFTMVYTVT WLFFGFIWWL IAYIRGDLDH 
121:	VGDQEWIPCV ENLSGFVSAF LFSIETETTI GYGFRVITEK CPEGIILLLV QAILGSIVNA 
181:	FMVGCMFVKI SQPKKRAETL MFSNNAVISM RDEKLCLMFR VGDLRNSHIV EASIRAKLIK 
241:	SRQTKEGEFI PLNQTDINVG FDTGDDRLFL VSPLIISHEI NQKSPFWEMS QAQLHQEEFE 
301:	VVVILEGMVE ATGMTCQARS SYMDTEVLWG HRFTPVLTLE KGFYEVDYNT FHDTYETNTP 
361:	SCCAKELAEM KREGRLLQYL PSPPLLGGCA EAGLDAEAEQ NEEDEPKGLG GSREARGSV