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1.A.2.1.5
Cranial nerve inward rectifying K+ channel, Kir2.4 (IRK4) (Töpert et al., 1998)

Accession Number:O70596
Protein Name:ATP-sensitive inward rectifier potassium channel 14 aka IRK4 aka Kir2.4
Length:434
Molecular Weight:47609.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

Genevestigator: O70596
eggNOG: maNOG08316
RefSeq: NP_733836.1   
Entrez Gene ID: 276720   
Pfam: PF01007   
KEGG: rno:276720   

Gene Ontology

GO:0030425 C:dendrite
GO:0016021 C:integral to membrane
GO:0043025 C:neuronal cell body
GO:0005242 F:inward rectifier potassium channel activity
GO:0006813 P:potassium ion transport

References (1)

[1] “Kir2.4: a novel K+ inward rectifier channel associated with motoneurons of cranial nerve nuclei.”  Toepert C.et.al.   9592090

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGLARALRRL SGALEPGNSR AGDEEEAGAG LCRNGWAPGP VAGNRRRGRF VKKDGHCNVR 
61:	FVNLGGQGAR YLSDLFTTCV DVRWRWMCLL FSCSFLASWL LFGLTFWLIA SLHGDLAAPP 
121:	PPAPCFSQVA SFLAAFLFAL ETQTSIGYGV RSVTEECPAA VAAVVLQCIA GCVLDAFVVG 
181:	AVMAKMAKPK KRNETLVFSE NAVVALRDRR LCLMWRVGNL RRSHLVEAHV RAQLLQPRVT 
241:	PEGEYIPLDH QDVDVGFDGG TDRIFLVSPI TIVHEIDSAS PLYELGRAEL ARADFELVVI 
301:	LEGMVEATAM TTQCRSSYLP GELLWGHRFE PVLFQRGSQY EVDYRHFHRT YEVPGTPVCS 
361:	AKELDERAEQ ASHSPKSSFP GSLAAFCYEN ELALSCCQEE DEEEDTKEGT SAETPDRAAS 
421:	PQALTPTLAL TLPP