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1.A.2.1.8
The inward rectifier potassium channel 13, Kir 7.1

Accession Number:O60928
Protein Name:Inward rectifier potassium channel 13 aka Kir7.1
Length:360
Molecular Weight:40530.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

Genevestigator: O60928
eggNOG: prNOG19555
HEGENOM: HBG716702
RefSeq: NP_001165887.1    NP_001165888.1    NP_002233.2   
Entrez Gene ID: 3769   
Pfam: PF01007   
OMIM: 193230  phenotype
603208  gene
KEGG: hsa:3769   

Gene Ontology

GO:0008076 C:voltage-gated potassium channel complex
GO:0005242 F:inward rectifier potassium channel activity
GO:0006813 P:potassium ion transport

References (5)

[1] “Cloning and characterization of a novel human inwardly rectifying potassium channel predominantly expressed in small intestine.”  Partiseti M.et.al.   9738472
[2] “A novel inward rectifier K+ channel with unique pore properties.”  Krapivinsky G.et.al.   9620703
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Partial gene structure and assignment to chromosome 2q37 of the human inwardly rectifying K+ channel (Kir7.1) gene (KCNJ13).”  Derst C.et.al.   9878260
[5] “Mutations in KCNJ13 cause autosomal-dominant snowflake vitreoretinal degeneration.”  Hejtmancik J.F.et.al.   18179896

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MDSSNCKVIA PLLSQRYRRM VTKDGHSTLQ MDGAQRGLAY LRDAWGILMD MRWRWMMLVF 
61:	SASFVVHWLV FAVLWYVLAE MNGDLELDHD APPENHTICV KYITSFTAAF SFSLETQLTI 
121:	GYGTMFPSGD CPSAIALLAI QMLLGLMLEA FITGAFVAKI ARPKNRAFSI RFTDTAVVAH 
181:	MDGKPNLIFQ VANTRPSPLT SVRVSAVLYQ ERENGKLYQT SVDFHLDGIS SDECPFFIFP 
241:	LTYYHSITPS SPLATLLQHE NPSHFELVVF LSAMQEGTGE ICQRRTSYLP SEIMLHHCFA 
301:	SLLTRGSKGE YQIKMENFDK TVPEFPTPLV SKSPNRTDLD IHINGQSIDN FQISETGLTE