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1.A.2.1.9
The inward-rectifier k+ channel, Kir2.2 at the 3-d structure at 3.1 Å resolution is available (Tao et al., 2009). (70%v identical to Kir2.1 (TC # 1.A.2.1.2)). The structural basis of PIP2 activation of Kir2.2 has been presented (Hansen et al., 2011).

Accession Number:Q14500
Protein Name:ATP-sensitive inward rectifier potassium channel 12
Length:433
Molecular Weight:49001.00
Species: [9606]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

Genevestigator: Q14500
eggNOG: prNOG08425
HEGENOM: HBG716702
RefSeq: NP_066292.2    XP_001718688.2    XP_002347768.1   
Entrez Gene ID: 100131509    100290070    3768   
Pfam: PF01007    PF08466   
Drugbank: Drugbank Link   
OMIM: 602323  gene
KEGG: hsa:100131509    hsa:100290070    hsa:3768   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005242 F:inward rectifier potassium channel activity
GO:0008200 F:ion channel inhibitor activity
GO:0015459 F:potassium channel regulator activity
GO:0008015 P:blood circulation
GO:0006936 P:muscle contraction
GO:0006813 P:potassium ion transport
GO:0008016 P:regulation of heart contraction

References (6)

[1] “Cloning and functional expression of an inwardly rectifying K+ channel from human atrium.”  Wible B.A.et.al.   7859381
[2] “Kir2.2v: a possible negative regulator of the inwardly rectifying K+ channel Kir2.2.”  Namba N.et.al.   8647284
[3] “Identification of human Kir2.2 (KCNJ12) gene encoding functional inward rectifier potassium channel in both mammalian cells and Xenopus oocytes.”  Kaibara M.et.al.   12417321
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “An alternate promoter directs expression of a truncated, muscle-specific isoform of the human ankyrin 1 gene.”  Gallagher P.G.et.al.   9430667
[6] “A quantitative atlas of mitotic phosphorylation.”  Dephoure N.et.al.   18669648

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTAASRANPY SIVSSEEDGL HLVTMSGANG FGNGKVHTRR RCRNRFVKKN GQCNIEFANM 
61:	DEKSQRYLAD MFTTCVDIRW RYMLLIFSLA FLASWLLFGI IFWVIAVAHG DLEPAEGRGR 
121:	TPCVMQVHGF MAAFLFSIET QTTIGYGLRC VTEECPVAVF MVVAQSIVGC IIDSFMIGAI 
181:	MAKMARPKKR AQTLLFSHNA VVALRDGKLC LMWRVGNLRK SHIVEAHVRA QLIKPRVTEE 
241:	GEYIPLDQID IDVGFDKGLD RIFLVSPITI LHEIDEASPL FGISRQDLET DDFEIVVILE 
301:	GMVEATAMTT QARSSYLANE ILWGHRFEPV LFEEKNQYKI DYSHFHKTYE VPSTPRCSAK 
361:	DLVENKFLLP SANSFCYENE LAFLSRDEED EADGDQDGRS RDGLSPQARH DFDRLQAGGG 
421:	VLEQRPYRRE SEI