TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


1.A.2.2.1
Prokaryotic K+-selective Kir channel KirBac1.1 (selectivity: K+ = Rb+ = Cs+ >> Li, Na+ or NMGM) (Enkvetchakul et al., 2004), inward rectifying (Cheng et al., 2009). The inhibitory cholesterol binding site has been identified (Fürst et al. 2014).

Accession Number:P83698
Protein Name:Inward rectifier potassium channel protein
Length:333
Molecular Weight:37133.00
Species:Burkholderia pseudomallei (Pseudomonas pseudomallei) [28450]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Apical cell membrane1 / Multi-pass membrane protein2
Substrate K+

Cross database links:

HEGENOM: HBG480115
RefSeq: YP_106981.1   
Entrez Gene ID: 3094088   
Pfam: PF01007   
BioCyc: BPSE272560:BPSL0355-MONOMER   
KEGG: bps:BPSL0355   

Gene Ontology

GO:0016020 C:membrane
GO:0005242 F:inward rectifier potassium channel activity
GO:0006813 P:potassium ion transport

References (2)

[1] “Crystal structure of the potassium channel KirBac1.1 in the closed state.”  Kuo A.et.al.   12738871
[2] “Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei.”  Holden M.T.G.et.al.   15377794
Structure:
1P7B   2WLL     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MNVDPFSPHS SDSFAQAASP ARKPPRGGRR IWSGTREVIA YGMPASVWRD LYYWALKVSW 
61:	PVFFASLAAL FVVNNTLFAL LYQLGDAPIA NQSPPGFVGA FFFSVETLAT VGYGDMHPQT 
121:	VYAHAIATLE IFVGMSGIAL STGLVFARFA RPRAKIMFAR HAIVRPFNGR MTLMVRAANA 
181:	RQNVIAEARA KMRLMRREHS SEGYSLMKIH DLKLVRNEHP IFLLGWNMMH VIDESSPLFG 
241:	ETPESLAEGR AMLLVMIEGS DETTAQVMQA RHAWEHDDIR WHHRYVDLMS DVDGMTHIDY 
301:	TRFNDTEPVE PPGAAPDAQA FAAKPGEGDA RPV