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1.A.20.1.2
NIP3L (NIP3-like protein X; Adenovirus E1B 19kDa-binding protein B5). 

Accession Number:O60238
Protein Name:BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like aka NIP3L
Length:219
Molecular Weight:23930.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Nucleus envelope1 / Single-pass membrane protein2
Substrate small molecules

Cross database links:

Genevestigator: O60238
eggNOG: prNOG13187
RefSeq: NP_004322.1   
Entrez Gene ID: 665   
Pfam: PF06553   
OMIM: 605368  gene
KEGG: hsa:665   

Gene Ontology

GO:0005783 C:endoplasmic reticulum
GO:0016021 C:integral to membrane
GO:0005740 C:mitochondrial envelope
GO:0005635 C:nuclear envelope
GO:0005521 F:lamin binding
GO:0046982 F:protein heterodimerization activity
GO:0042803 F:protein homodimerization activity
GO:0006915 P:apoptosis
GO:0051607 P:defense response to virus
GO:0006917 P:induction of apoptosis
GO:0044419 P:interspecies interaction between organisms
GO:0008634 P:negative regulation of survival gene produc...

References (8)

[1] “Isolation, mapping, and functional analysis of a novel human cDNA (BNIP3L) encoding a protein homologous to human NIP3.”  Matsushima M.et.al.   9523198
[2] “Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins.”  Chen G.et.al.   9867803
[3] “A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region.”  Ohi N.et.al.   10381623
[4] “The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation.”  Aerbajinai W.et.al.   12663450
[5] “The full-ORF clone resource of the German cDNA consortium.”  Bechtel S.et.al.   17974005
[6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[7] “The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase.”  Passer B.J.et.al.   12606722
[8] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.”  Olsen J.V.et.al.   17081983

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
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FASTA formatted sequence
1:	MSSHLVEPPP PLHNNNNNCE ENEQSLPPPA GLNSSWVELP MNSSNGNDNG NGKNGGLEHV 
61:	PSSSSIHNGD MEKILLDAQH ESGQSSSRGS SHCDSPSPQE DGQIMFDVEM HTSRDHSSQS 
121:	EEEVVEGEKE VEALKKSADW VSDWSSRPEN IPPKEFHFRH PKRSVSLSMR KSGAMKKGGI 
181:	FSAEFLKVFI PSLFLSHVLA LGLGIYIGKR LSTPSASTY