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1.A.21.1.6
Bcl-XL of 289 aas, a C-tail-anchored mitochondrial outer membrane protein (Setoguchi et al. 2006). The BH4 domain of Bcl-XL, but not that of Bcl-2, selectively targets VDAC1 and inhibits apoptosis by decreasing VDAC1-mediated Ca2+ uptake into mitochondria (Monaco et al. 2015). The ER-mitochondrion interface is a critical cell-signaling junction whereby Bcl-xL dynamically interacts with type 3 inositol 1,4,5-trisphosphate receptors (IP3R3) to coordinate mitochondrial Ca2+ transfer and alters cellular metabolism in order to increase the cells' bioenergetic capacity, particularly during periods of stress (Williams et al. 2016).

Accession Number:Q2TAP5
Protein Name:Bcl-XL protein
Length:204
Molecular Weight:23171.00
Species:Xenopus laevis (African clawed frog) [8355]
Number of TMSs:1
Substrate cytochrome c, small molecules

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FASTA formatted sequence
1:	MEGSSRDLVE KFVSKKLSQN EACRKFSNNP QPNAISNGTS TSERPGEGAT QGIVEEEVLQ 
61:	ALLEATEEFE LRYQRAFSDL TSQLHITQDT AQQSFQQVMG ELFRDGTNWG RIVAFFSFGR 
121:	ALCVESANKE MTDLLPRIVQ WMVNYLEHTL QPWMQENGGW EAFVGLYGKN AAAQSRESQE 
181:	RFGRLLTIVI LTGVFALVCY MRRR