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1.A.21.2.1
The Cell Death (CED-9) protein (Siskind et al., 2008)

Accession Number:P41958
Protein Name:CED-9
Length:280
Molecular Weight:31824.00
Species:Caenorhabditis elegans [6239]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Endomembrane system1 / Peripheral membrane protein2
Substrate cytochrome c

Cross database links:

eggNOG: KOG4728
HEGENOM: HBG382823
DIP: DIP-250N
RefSeq: NP_499284.1   
Entrez Gene ID: 3565776   
Pfam: PF00452    PF02180   
KEGG: cel:T07C4.8   

Gene Ontology

GO:0012505 C:endomembrane system
GO:0031966 C:mitochondrial membrane
GO:0005515 F:protein binding
GO:0006915 P:apoptosis
GO:0009792 P:embryonic development ending in birth or eg...
GO:0042981 P:regulation of apoptosis

References (8)

[1] “C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2.”  Hengartner M.O.et.al.   7907274
[2] “Genome sequence of the nematode C. elegans: a platform for investigating biology.”  The C. elegans sequencing consortiumet.al.   9851916
[3] “Interaction between the C. elegans cell-death regulators CED-9 and CED-4.”  Spector M.S.et.al.   9024666
[4] “Interaction and regulation of subcellular localization of CED-4 by CED-9.”  Wu D.et.al.   9027313
[5] “The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9.”  Conradt B.et.al.   9604928
[6] “Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death.”  Chen F.et.al.   10688797
[7] “Unique structural features of a BCL-2 family protein CED-9 and biophysical characterization of CED-9/EGL-1 interactions.”  Woo J.-S.et.al.   12894216
[8] “Structural, biochemical, and functional analyses of CED-9 recognition by the proapoptotic proteins EGL-1 and CED-4.”  Yan N.et.al.   15383288
Structure:
1OHU   1TY4   2A5Y     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTRCTADNSL TNPAYRRRTM ATGEMKEFLG IKGTEPTDFG INSDAQDLPS PSRQASTRRM 
61:	SIGESIDGKI NDWEEPRLDI EGFVVDYFTH RIRQNGMEWF GAPGLPCGVQ PEHEMMRVMG 
121:	TIFEKKHAEN FETFCEQLLA VPRISFSLYQ DVVRTVGNAQ TDQCPMSYGR LIGLISFGGF 
181:	VAAKMMESVE LQGQVRNLFV YTSLFIKTRI RNNWKEHNRS WDDFMTLGKQ MKEDYERAEA 
241:	EKVGRRKQNR RWSMIGAGVT AGAIGIVGVV VCGRMMFSLK