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1.A.22.1.2
Large mechanosensitive ion channel (3-D structure known)

Accession Number:P0A5K8
Protein Name:Large-conductance mechanosensitive channel MscL aka RV0985C
Length:151
Molecular Weight:16023.00
Species:Mycobacterium tuberculosis [1773]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate ions

Cross database links:

HEGENOM: HBG727604
RefSeq: NP_215500.1    NP_335447.1   
Entrez Gene ID: 885368    925186   
Pfam: PF01741   
KEGG: mtc:MT1013    mtu:Rv0985c   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005216 F:ion channel activity
GO:0006811 P:ion transport

References (2)

[1] “Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.”  Cole S.T.et.al.   9634230
[2] “Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.”  Fleischmann R.D.et.al.   12218036
Structure:
2oar     

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
Window Size: Angle:  
FASTA formatted sequence
1:	MLKGFKEFLA RGNIVDLAVA VVIGTAFTAL VTKFTDSIIT PLINRIGVNA QSDVGILRIG 
61:	IGGGQTIDLN VLLSAAINFF LIAFAVYFLV VLPYNTLRKK GEVEQPGDTQ VVLLTEIRDL 
121:	LAQTNGDSPG RHGGRGTPSP TDGPRASTES Q