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1.A.22.1.5
The pentameric MscL channel (Iscla et al., 2011).  The high resolution structure of a proposed closed but expanded tetrameric intermediate state has been determined (Liu et al. 2009).

Accession Number:P68805
Protein Name:Large-conductance mechanosensitive channel
Length:120
Molecular Weight:13616.00
Species:Staphylococcus aureus (strain NCTC 8325) [93061]
Number of TMSs:2
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate ions

Cross database links:

HEGENOM: HBG727604
Pfam: PF01741   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005216 F:ion channel activity

References (1)

[1] “Functional and structural conservation in the mechanosensitive channel mscL implicates elements crucial for mechanosensation.”  Moe P.C.et.al.   9632260

External Searches:

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  • CDD Search (Conserved Domain Database)
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  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLKEFKEFAL KGNVLDLAIA VVMGAAFNKI ISSLVENIIM PLIGKIFGSV DFAKEWSFWG 
61:	IKYGLFIQSV IDFIIIAFAL FIFVKIANTL MKKEEAEEEA VVEENVVLLT EIRDLLREKK